Acifluorfen

Modify Date: 2024-01-05 12:12:09

Acifluorfen structure	Common Name	Acifluorfen
	CAS Number	50594-66-6	Molecular Weight	361.657
	Density	1.6±0.1 g/cm3	Boiling Point	422.4±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₇ClF₃NO₅	Melting Point	161ºC
	MSDS	Chinese USA	Flash Point	209.2±28.7 °C
	Symbol	GHS05, GHS07, GHS09	Signal Word	Danger

Use of Acifluorfen

Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species[1][2].

Name	acifluorfen
Synonym	More Synonyms

Description	Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	The effect of Acifluorfen on glutathione and ascorbate levels in cucumber (Cucumis sativus L.) cotyledon discs is investigated to assess the relationship between herbicide activity and endogenous antioxidants. Acifluorfen decreases the levels of glutathione and ascorbate over 50% in discs exposed to less than 1.5 hours of white light (450 microeinsteins per square meter per second). Acifluorfen also causes the rapid depletion of ascorbate in far-red light grown plants which are photosynthetically incompetent[2].
In Vivo	Dietary treatment with 2500 ppm Acifluorfen for up to 13 weeks increases Cyp2b10 expression in the livers of wild-type mice, but not in CAR-knockout (CARKO) mice. Microscopically, Acifluorfen treatment-induces cytotoxic changes, including hepatocellular necrosis and inflammation, and causes regenerative changes accompanied by prolonged increases in the numbers of proliferating cell nuclear antigen-positive hepatocytes in WT mice[1].
References	[1]. Kuwata K, et al. Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. Toxicol Sci. 2016;151(2):271-285. [2]. Kenyon WH, et al. Effects of Acifluorfen on Endogenous Antioxidants and Protective Enzymes in Cucumber (Cucumis sativus L.) Cotyledons. Plant Physiol. 1985;79(3):862-866.

Density	1.6±0.1 g/cm3
Boiling Point	422.4±45.0 °C at 760 mmHg
Melting Point	161ºC
Molecular Formula	C₁₄H₇ClF₃NO₅
Molecular Weight	361.657
Flash Point	209.2±28.7 °C
Exact Mass	360.996490
PSA	92.35000
LogP	4.35
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.576
Storage condition	0-6°C

Acifluorfen MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG5643070

CHEMICAL NAME :: Benzoic acid, 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitro-

CAS REGISTRY NUMBER :: 50594-66-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H7-Cl-F3-N-O5

MOLECULAR WEIGHT :: 361.67

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,6,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6900 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,6,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,6,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,6,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,6,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 2821 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,6,1991

Symbol	GHS05, GHS07, GHS09
Signal Word	Danger
Hazard Statements	H302-H315-H318-H410
Precautionary Statements	P273-P280-P305 + P351 + P338-P501
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R22;R38;R41;R50/53
Safety Phrases	S24-S39-S60-S61
RIDADR	UN 3077
RTECS	DG5643070
Packaging Group	III
HS Code	2918990027

3-(2-Chloro-4-(...

CAS#:63734-62-3

Acifluorfen

CAS#:50594-66-6

Literature: Rohm and Haas Company Patent: US4031131 A1, 1977 ;

Acifluorfen met...

CAS#:50594-67-7

Acifluorfen

CAS#:50594-66-6

Literature: Rohm and Haas Company Patent: US4395570 A1, 1983 ;

3-(2-Chloro-4-(...

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dichloroethane

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Acifluorfen

CAS#:50594-66-6

Literature: Rohm and Haas Company Patent: US4031131 A1, 1977 ;

chlordimeform hcl

CAS#:19750-95-9

Acifluorfen

CAS#:50594-66-6

Literature: Zeneca Limited Patent: US6342630 B1, 2002 ; Location in patent: Example 2 ;

Precursor 4
CAS#:63734-62-3 3-(2-Chloro-4-(... CAS#:50594-67-7 Acifluorfen met... CAS#:107-06-2 dichloroethane CAS#:19750-95-9 chlordimeform hcl
DownStream 10
CAS#:100-02-7 4-Nitrophenol CAS#:42874-01-1 nitrofluorfen CAS#:35852-58-5 2-Chloro-4-(tri... CAS#:610-37-7 5-Hydroxy-2-nit...
CAS#:50594-67-7 Acifluorfen met... CAS#:19750-95-9 chlordimeform hcl CAS#:98-88-4 Benzoyl chloride CAS#:67446-83-7 5-[2-chloro-4-(...
CAS#:72178-02-0 Fomesafen CAS#:77501-90-7 fluoroglycofen-ethyl

HS Code	2918990027
Summary	2918990027 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

[Determination of biphenyl ether herbicides in water using HPLC with cloud-point extraction].

Sichuan Da Xue Xue Bao. Yi Xue Ban 41(1) , 148-52, (2010)

To determine residues of multiple biphenyl ether herbicides simultaneously in water using high performance liquid chromatography (HPLC) with cloud-point extraction.The residues of eight biphenyl ether...

Increased expression of Fe-chelatase leads to increased metabolic flux into heme and confers protection against photodynamically induced oxidative stress.

Plant Mol. Biol. 86(3) , 271-87, (2014)

Fe-chelatase (FeCh, EC 4.99.1.1) inserts Fe(2+) into protoporphyrin IX (Proto IX) to form heme, which influences the flux through the tetrapyrrole biosynthetic pathway as well as fundamental cellular ...

Photochemistry and photoinduced toxicity of acifluorfen, a diphenyl-ether herbicide.

J. Environ. Qual. 31(1) , 268-74, (2002)

Photochemistry studies can be helpful in assessing the environmental fate of chemicals. Photochemical reactions lead to the formation of by-products that can exhibit different toxicological properties...

EINECS 256-634-5

5-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid

Acifluorfen ∆

WNR BVQ DOR BG DXFFF

Acifluorofen

5-(2-Chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoic acid

5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-nitrobenzoic acid

5-{[2-Chloro-4-(trifluoromethyl)phenyl]oxy}-2-nitrobenzoic acid

Benzoic acid, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitro-

5-(2-Chloro-4-trifluoromethylphenoxy)-2-nitrobenzoic acid

Acifluorfen

MFCD00143541

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China
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China
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China
Product Name: Acifluorfen
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Purity: 98.0%
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