Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)-

Modify Date: 2024-01-06 18:40:15

Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)- structure	Common Name	Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)-
	CAS Number	50722-38-8	Molecular Weight	322.353
	Density	1.4±0.1 g/cm3	Boiling Point	529.8±50.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₂O₇	Melting Point	185.75°C
	MSDS	Chinese USA	Flash Point	195.2±23.6 °C
	Symbol	GHS06	Signal Word	Danger

Use of Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)-

3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative[1], is a blood-brain barrier (BBB) permeable mycotoxin[2].

Name	3-Acetyldeoxynivalenol
Synonym	More Synonyms

Description	3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative[1], is a blood-brain barrier (BBB) permeable mycotoxin[2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Kadota T, et al. Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenolon intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol In Vitro. 2013 Sep;27(6):1888-95. [2]. Behrens M, et al. Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain. PLoS One. 2015 Nov 23;10(11):e0143640.

Description

3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative[1], is a blood-brain barrier (BBB) permeable mycotoxin[2].

Related Catalog

Research Areas >> Cardiovascular Disease

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Kadota T, et al. Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenolon intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol In Vitro. 2013 Sep;27(6):1888-95.

[2]. Behrens M, et al. Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain. PLoS One. 2015 Nov 23;10(11):e0143640.

Density	1.4±0.1 g/cm3
Boiling Point	529.8±50.0 °C at 760 mmHg
Melting Point	185.75°C
Molecular Formula	C₁₇H₂₂O₇
Molecular Weight	322.353
Flash Point	195.2±23.6 °C
Exact Mass	322.141632
PSA	96.36000
LogP	-0.85
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.598

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD0150000

CHEMICAL NAME :: Trichothec-9-en-8-one, 3-(acetyloxy)-7,15-dihydroxy-, (3-alpha,7-alpha)-

CAS REGISTRY NUMBER :: 50722-38-8

LAST UPDATED :: 198910

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H22-O7

MOLECULAR WEIGHT :: 338.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year: 15,261,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H311-H331
Precautionary Statements	P261-P264-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;F: Flammable;Xn: Harmful;
Risk Phrases	R23/24/25
Safety Phrases	S45;S36/S37
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	YD0150000
Packaging Group	I
Hazard Class	6.1(a)

Precursor 0
DownStream 3
CAS#:51481-10-8 DEOXYNIVALENOL CAS#:88337-96-6 15-Acetyl-deoxy... CAS#:51550-28-8 Trichothec-9-en...

Development and validation of a high performance liquid chromatographic-mass spectrometry method for the simultaneous quantification of 10 trichothecenes in ultra-high temperature processed cow milk.

J. Chromatogr. A. 1419 , 37-44, (2015)

An LC-MS/MS (QqQ) method has been developed and validated for simultaneous determination of the following trichothecenes in UHT cow milk: nivalenol (NIV), deoxynivalenol (DON), deepoxy-deoxynivalenol ...

Preliminary estimation of deoxynivalenol excretion through a 24 h pilot study.

Toxins (Basel.) 7 , 705-18, (2015)

A duplicate diet study was designed to explore the occurrence of 15 Fusarium mycotoxins in the 24 h-diet consumed by one volunteer as well as the levels of mycotoxins in his 24 h-collected urine. The ...

Innate Immune Sensing of Fusarium culmorum by Mouse Dendritic Cells.

J. Toxicol. Environ. Health A 78 , 871-85, (2015)

Chronic inhalation of grain dust is associated with asthma and chronic bronchitis in grain worker populations. Exposure to fungal particles was postulated to be an important etiologic agent of these p...

MFCD00135964

Trichothec-9-en-8-one, 3-acetyl-12,13-epoxy-7,15-dihydroxy-, (3β,5α,6β,7β,11β,12ξ)-

3-acetyldeoxynivalenol

(2α,3β,5α,6β,7β,11β,12ξ)-3-Acetyl-7,15-dihydroxy-12,13-epoxytrichothec-9-en-8-one

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)-
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 3-acetyldeoxynivalenol
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)- suppliers

Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)- price

Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)-

Use of Trichothec-9-en-8-one,3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-, (3a,7a)-

Names

Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Precursor & DownStream

Articles39

Synonyms