Delsoline

Modify Date: 2024-01-06 14:11:09

Delsoline Structure
Delsoline structure
 Common Name Delsoline
CAS Number 509-18-2 Molecular Weight 467.595
Density 1.3±0.1 g/cm3 Boiling Point 576.0±50.0 °C at 760 mmHg
Molecular Formula C25H41NO7 Melting Point 214ºC
MSDS N/A Flash Point 302.1±30.1 °C

 Use of Delsoline


Delsoline, a major alkaloid of Delphinium anthriscifolium Hance, has both a curare-like effect and a ganglion-blocking effect and is used to relieve muscle tension or hyperkinesia. D. anthriscifolium Hance has effects of dispelling wind and dampness, activating collaterals, and relieving pains and is used to treat rheumatism, hemiplegia, indigestion, and cough[1].

 Names

Name (1α,6β,8ξ,14α,16β,17R)-20-Ethyl-6,14,16-trimethoxy-4-(methoxymeth yl)aconitane-1,7,8-triol
Synonym More Synonyms

 Delsoline Biological Activity

Description Delsoline, a major alkaloid of Delphinium anthriscifolium Hance, has both a curare-like effect and a ganglion-blocking effect and is used to relieve muscle tension or hyperkinesia. D. anthriscifolium Hance has effects of dispelling wind and dampness, activating collaterals, and relieving pains and is used to treat rheumatism, hemiplegia, indigestion, and cough[1].
Related Catalog
References

[1]. Shao L, et al. Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood. J Anal Methods Chem. 2018 Oct 11;2018:9412708.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 576.0±50.0 °C at 760 mmHg
Melting Point 214ºC
Molecular Formula C25H41NO7
Molecular Weight 467.595
Flash Point 302.1±30.1 °C
Exact Mass 467.288300
PSA 100.85000
LogP -0.27
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.596
Storage condition 2-8C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR5569490
CHEMICAL NAME :
Aconitane-1,7,8-triol, 20-ethyl-4-(methoxymethyl)-6,14,16-trimethoxy-, (1-alpha,6-beta,14-alpha,16-beta)-
CAS REGISTRY NUMBER :
509-18-2
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C25-H41-N-O7
MOLECULAR WEIGHT :
467.67

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

 Safety Information

RTECS AR5569490

 Synthetic Route

Delcosine structure

Delcosine

CAS#:545-56-2

methyl iodide structure

methyl iodide

CAS#:74-88-4

~52%

Delsoline Structure

Delsoline

CAS#:509-18-2

Literature: Wada, Koji; Mori, Takao; Kawahara, Norio Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 660 - 668
14-Acetyldelcosine structure

14-Acetyldelcosine

CAS#:50676-21-6

~%

Delsoline Structure

Delsoline

CAS#:509-18-2

Literature: Wada, Koji; Mori, Takao; Kawahara, Norio Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 660 - 668
(3aR,5S,6R,7S,7aR,8R,8aS,9S,12S,14aS,14bS,15S,16R)-14-ethyl-5,7,15-trimethoxy-12-(methoxymethyl)dodecahydro-9H-8a,12,14b-(epiethane[1,1,2]triyl)-6,8-methano[1,3]dioxolo[4',5':1,8a]naphtho[2,3-b]azocin-9-ol structure

(3aR,5S,6R,7S,7...

CAS#:116197-13-8

~%

Delsoline Structure

Delsoline

CAS#:509-18-2

Literature: Salimov Chemistry of Natural Compounds, 2001 , vol. 37, # 3 p. 272 - 273

 Synonyms

Xuan-Wu 3
Bullatine-B
Dideacetyldelphisine
20-Ethyl-6,16-dimethoxy-4-(methoxymethyl)aconitane-1,8,14-triol
Delsoline
(1α,6β,14α,16β)-20-Ethyl-6,14,16-trimethoxy-4-(methoxymethyl)aconitane-1,7,8-triol
Aconitane-1,7,8-triol, 20-ethyl-6,14,16-trimethoxy-4-(methoxymethyl)-, (1α,6β,14α,16β)-
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