2-Pyridinealdoxime methochloride

Modify Date: 2024-01-02 19:12:42

2-Pyridinealdoxime methochloride structure	Common Name	2-Pyridinealdoxime methochloride
	CAS Number	51-15-0	Molecular Weight	172.612
	Density	N/A	Boiling Point	189.7ºC at760mmHg
	Molecular Formula	C₇H₉ClN₂O	Melting Point	215-225 ºC
	MSDS	Chinese USA	Flash Point	68.5ºC
	Symbol	GHS07	Signal Word	Warning

Use of 2-Pyridinealdoxime methochloride

Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents) in conjunction with atropine and diazepam.

Name	pralidoxime chloride
Synonym	More Synonyms

Description	Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents) in conjunction with atropine and diazepam.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease

Boiling Point	189.7ºC at760mmHg
Melting Point	215-225 ºC
Molecular Formula	C₇H₉ClN₂O
Molecular Weight	172.612
Flash Point	68.5ºC
Exact Mass	172.040344
PSA	36.47000
Storage condition	0-6°C
Water Solubility	65.5 g/100 mL (25 ºC)

2-Pyridinealdoxime methochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU4200000

CHEMICAL NAME :: Pyridinium, 2-formyl-1-methyl-, chloride, oxime

CAS REGISTRY NUMBER :: 51-15-0

LAST UPDATED :: 199603

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C7-H9-N2-O.Cl

MOLECULAR WEIGHT :: 172.63

WISWESSER LINE NOTATION :: T6KJ A1 B1UNQ &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - bronchiolar constriction Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,449,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 15,599,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,40,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,40,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 155 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,5,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,5,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,431,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S106,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 132,50,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 168 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,40,1970 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 50,475,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6078 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 968 (estimated) No. of Female Employees: 494 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P261-P280-P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/22;R36/37/38
Safety Phrases	S36-S37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UU4200000
HS Code	2933399090

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Literature: Unnisa, Lateef; Sumakanth; Rao, B. Leelamaheswara; Divi, Murali Krishnaprasad; Rao, Mysore Aswathanarayana Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014 , vol. 53, # 4 p. 431 - 435

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Precursor 3
CAS#:154-97-2 pralidoxime mesilate CAS#:70275-57-9 1-Methyl-2-pyri... CAS#:873-69-8 2-Pyridinecarba...
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Development and validation of a FIA/UV-vis method for pK(a) determination of oxime based acetylcholinesterase reactivators.

J. Pharm. Biomed. Anal. 117 , 240-6, (2015)

Acetylcholinesterase reactivators (oximes) are compounds used for antidotal treatment in case of organophosphorus poisoning. The dissociation constants (pK(a1)) of ten standard or promising acetylchol...

An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.

J. Biomol. Screen. 18(1) , 108-15, (2013)

Organophosphates are a class of highly toxic chemicals that includes many pesticides and chemical weapons. Exposure to organophosphates, either through accidents or acts of terrorism, poses a signific...

Chlorpyrifos is associated with slower serum cholinesterase recovery in acute organophosphate-poisoned patients.

Clin. Toxicol. (Phila.) 51(5) , 402-8, (2013)

Organophosphate poisoning (OPP) accounts for 200,000 deaths annually in developing countries. Serum cholinesterase (SChE) is of diagnostic value in patients with OPP and is checked repeatedly during t...

Pyraloximi Methchlordum

protopamchloride

1-methyl-2-pyridine aldoxyme chloride

2-[(E)-(Hydroxyimino)methyl]-1-methylpyridinium chloride

2-Pyridine aldoxime methyl chloride

pralidoxime

EINECS 200-080-9

pyridinium, 2-[(hydroxyimino)methyl]-1-methyl-, chloride (1:1)

2-Pyridinealdoxime methochloride

Pralidoxome Chloride

Pralidoxime Chloride

pyridinium, 2-[(E)-(hydroxyimino)methyl]-1-methyl-, chloride

2-PAM CHLORIDE

2-[hydroxyimino ethyl]-1-methylpyridinium chloride

MFCD00011981

Protopam

Pyridine-2-aldoxiMe Meth

PRALIDOXIMECHLORIDE,USP

2-[(Hydroxyimino)methyl]-1-methylpyridinium chloride

Pyridinium, 2-[(E)-(hydroxyimino)methyl]-1-methyl-, chloride (1:1)

2-PAM-Cl

1-MethylpyridiniuM-2-aldoxiMe Chloride

PAM CHLORIDE

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Pyridinealdoxime methochloride
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China
Product Name: 2-Pyridinealdoxime methochloride
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China
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China
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China
Product Name: 2-Pyridinealdoxime methochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Price: $66/10mM*1mLinDMSO

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2-Pyridinealdoxime methochloride

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