HBK

Modify Date: 2024-01-07 00:55:58

HBK Structure
HBK structure
Common Name HBK
CAS Number 51025-85-5 Molecular Weight 552.619
Density 1.5±0.1 g/cm3 Boiling Point 904.0±65.0 °C at 760 mmHg
Molecular Formula C22H44N6O10 Melting Point N/A
MSDS N/A Flash Point 500.5±34.3 °C

 Use of HBK


Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria[1].

 Names

Name arbekacin
Synonym More Synonyms

 HBK Biological Activity

Description Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria[1].
Related Catalog
In Vitro Arbekaci 有效抑制鲍氏不动杆菌 (MIC50=2 μg/mL) 和来自 PHP 的肠杆菌科 (MIC50=0.25-2 μg/mL; MIC90=1-8 μg/mL)[1]。 Arbekacin 也抑制全球范围内特征明确的耐多药革兰氏阴性和 MRSA 菌株[1]。
References

[1]. Matsumoto T. Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens. Clin Pharmacol. 2014 Sep 26;6:139-48.  

[2]. Sader HS, et al. Arbekacin activity against contemporary clinical bacteria isolated from patients hospitalized with pneumonia. Antimicrob Agents Chemother. 2015;59(6):3263-70.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 904.0±65.0 °C at 760 mmHg
Molecular Formula C22H44N6O10
Molecular Weight 552.619
Flash Point 500.5±34.3 °C
Exact Mass 552.311890
PSA 297.27000
LogP -4.00
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.635

 Synonyms

AHB-DKB
HBK
HABA-DKB
MFCD00864919
4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide
(S)-O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-erythrohexopyranosyl-(1®4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine
3-AMINO-2-METHOXY-4-PICOLINE
1-N-[(S)-4-Amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin B
Haberacin
Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy-
Arbekacin
1-N-[(S)-4-Amino-2-hydroxybutyryl]dibekacin