Wogonoside

Modify Date: 2024-01-02 15:42:17

Wogonoside Structure
Wogonoside structure
Common Name Wogonoside
CAS Number 51059-44-0 Molecular Weight 460.388
Density 1.6±0.1 g/cm3 Boiling Point 869.0±65.0 °C at 760 mmHg
Molecular Formula C22H20O11 Melting Point 226-227ºC
MSDS USA Flash Point 304.0±27.8 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Wogonoside


Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway[1][2].

 Names

Name (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid
Synonym More Synonyms

 Wogonoside Biological Activity

Description Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway[1][2].
Related Catalog
References

[1]. Yang YZ, et al. Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells. J Ethnopharmacol. 2013 Jun 21;148(1):271-6.

[2]. Sun Y, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013 Jan;51:53-60.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 869.0±65.0 °C at 760 mmHg
Melting Point 226-227ºC
Molecular Formula C22H20O11
Molecular Weight 460.388
Flash Point 304.0±27.8 °C
Exact Mass 460.100555
PSA 176.12000
LogP 1.42
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.685
Storage condition ?20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  2

DownStream  1

 Articles16

More Articles
Extraction and Bioactivity Analysis of Major Flavones Compounds from Scutellaria baicalensis Using In Vitro Assay and Online Screening HPLC-ABTS System.

J. Anal. Methods Chem. 2014 , 563702, (2014)

The extraction efficiency of a number of solvent compositions for the improvement of bioactive compounds yield from S. baicalensis has been investigated. Also, free radical scavengers in the glycoside...

Wogonoside induces autophagy-related apoptosis in human glioblastoma cells.

Oncol. Rep. 32(3) , 1179-87, (2014)

Wogonoside, a bioactive flavonoid extracted from the root of Scutellaria baicalensis Georgi, has shown preclinical anticancer efficacy in various cancer models. However, the effects of wogonoside on g...

Liquid Chromatography-Tandem Mass Spectrometry Screening Method for the Detection of Radical-Scavenging Natural Antioxidants from the Whole Scutellariae (Radix, Stem and Leaf).

J. Chromatogr. Sci. 53 , 1140-6, (2015)

A novel free radical reaction combined with high-performance LC-photodiode array-ESI-MS/MS screening method was developed for the detection and identification of natural antioxidants from whole Scutel...

 Synonyms

5-Hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranosiduronic acid
Oroxindin
Wogonin 7-β-D-glucuronide
wogonin 7-O-glucuronoside
wogonin 7-O-β-D-glucuronide
2-C-(5-Hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl)-D-glucuronic acid
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5-hydroxy-8-methoxy-2-phenyl-
Wogonin-7-O-|A-D-glucuronide
Wogonoside
Wogonin 7-O-glucuronide
Glychionide B
D-Glucuronic acid, 2-C-(5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl)-
5,7-dihydroxy-8-methoxyflavone 7-O-β-D-glucuronide
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