8-Br-cGMP(8-Bromo-cGMP)
8-Br-cGMP(8-Bromo-cGMP) structure
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Common Name | 8-Br-cGMP(8-Bromo-cGMP) | ||
|---|---|---|---|---|
| CAS Number | 51116-01-9 | Molecular Weight | 446.083 | |
| Density | 2.96 g/cm3 | Boiling Point | 794.3ºC at 760 mmHg | |
| Molecular Formula | C10H10BrN5NaO7P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 434.2ºC | |
Use of 8-Br-cGMP(8-Bromo-cGMP)8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2]. |
| Name | 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt |
|---|---|
| Synonym | More Synonyms |
| Description | 8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2]. |
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| Target |
PKG, Ca2+[1] |
| References |
| Density | 2.96 g/cm3 |
|---|---|
| Boiling Point | 794.3ºC at 760 mmHg |
| Molecular Formula | C10H10BrN5NaO7P |
| Molecular Weight | 446.083 |
| Flash Point | 434.2ºC |
| Exact Mass | 444.939880 |
| PSA | 187.45000 |
| LogP | 0.25780 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.
PLoS ONE 10 , e0134876, (2015) Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-c... |
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Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.
Br. J. Pharmacol. 171(24) , 5858-69, (2014) Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadi... |
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Platelet-derived HMGB1 is a critical mediator of thrombosis.
J. Clin. Invest. 125 , 4638-54, (2015) Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular patt... |
| 8-Br-cGMP 8-Bromo-cyclic GMP |
| EINECS 256-993-8 |
| sodium 8-bromo-3',5'-cyclic GMP |
| Sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide |
| 8-Bromo-cGMP, sodium salt,8-Bromoguanosinecyclic3',5'-monophosphatesodiumsalt |
| 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(4aR,6R,7R,7aS)-tetrahydro-2,7-dihydroxy-2-oxido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1) |
| MFCD00070128 |