Rubropunctamine

Modify Date: 2024-01-08 02:55:19

Rubropunctamine Structure
Rubropunctamine structure
Common Name Rubropunctamine
CAS Number 514-66-9 Molecular Weight 353.41200
Density 1.22g/cm3 Boiling Point 647.1ºC at 760 mmHg
Molecular Formula C21H23NO4 Melting Point N/A
MSDS N/A Flash Point 345.1ºC

 Use of Rubropunctamine


Rubropunctamine is a red azaphilone pigment isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctamine has anti-inflammation activities[1][2].

 Names

Name (9aR)-3-hexanoyl-9a-methyl-6-[(E)-prop-1-enyl]-7H-furo[3,2-g]isoquinoline-2,9-dione
Synonym More Synonyms

 Rubropunctamine Biological Activity

Description Rubropunctamine is a red azaphilone pigment isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctamine has anti-inflammation activities[1][2].
Related Catalog
In Vitro Rubropunctamine (0.32-32 nM; 48 h) inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), with an IC50 of 433 mol ratio/32 pmol TPA[1]. Rubropunctamine (1 h) exhibits moderate scavenging activity (inhibitory ratio (IR)=1.5) against NO generation by (±)-(E)-methyl-2[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1) in normal human hepato cells[1].
In Vivo Rubropunctamine inhibits TPA-induced inflammation in mice, with an ID50 of 0.32 mg/ear[1].
References

[1]. Akihisa T, et, al. Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects. J Agric Food Chem. 2005 Feb 9;53(3):562-5.

[2]. Patakova P. Monascus secondary metabolites: production and biological activity. J Ind Microbiol Biotechnol. 2013 Feb;40(2):169-81.

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 647.1ºC at 760 mmHg
Molecular Formula C21H23NO4
Molecular Weight 353.41200
Flash Point 345.1ºC
Exact Mass 353.16300
PSA 76.23000
LogP 3.06720
Index of Refraction 1.59

 Synonyms

Rubropunctamine