Dehydroglyasperin D

Modify Date: 2024-01-11 10:52:56

Dehydroglyasperin D Structure
Dehydroglyasperin D structure
Common Name Dehydroglyasperin D
CAS Number 517885-72-2 Molecular Weight 368.42
Density 1.2±0.1 g/cm3 Boiling Point 557.9±50.0 °C at 760 mmHg
Molecular Formula C22H24O5 Melting Point N/A
MSDS N/A Flash Point 291.2±30.1 °C

 Use of Dehydroglyasperin D


Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi[1][2][3].

 Names

Name 4-(5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl)benzene-1,3-diol
Synonym More Synonyms

 Dehydroglyasperin D Biological Activity

Description Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi[1][2][3].
Related Catalog
Target

COX-2[1]

References

[1]. Lee YS, et al. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. 2010;33(5):917-21.  

[2]. Jung SK, et al. MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo. J Cell Mol Med. 2015 Jan;19(1):135-42.  

[3]. Baek EJ, et al. Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes. J Microbiol Biotechnol. 2022 Aug 28;32(8):982-988.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 557.9±50.0 °C at 760 mmHg
Molecular Formula C22H24O5
Molecular Weight 368.42
Flash Point 291.2±30.1 °C
Exact Mass 368.162384
PSA 68.15000
LogP 6.18
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.605

 Safety Information

Hazard Codes Xi

 Synonyms

4-[(R)-5,7-Dimethoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-3-yl]-benzene-1,3-diol
4-((R)-5,7-Dimethoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-3-yl)-benzene-1,3-diol
1,3-Benzenediol, 4-[5,7-dimethoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-3-yl]-
4-[5,7-Dimethoxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-3-yl]-1,3-benzenediol
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