DAO-IN-1

Modify Date: 2024-01-02 17:05:54

DAO-IN-1 Structure
DAO-IN-1 structure
 Common Name DAO-IN-1
CAS Number 51856-25-8 Molecular Weight 167.19
Density 1.609 g/cm3 Boiling Point 437.4ºC at 760 mmHg
Molecular Formula C7H5NO2S Melting Point N/A
MSDS N/A Flash Point 218.3ºC

 Use of DAO-IN-1


DAO-IN-1 is a potent inhibitor of D-amino acid oxidase (DAO) with an IC50 value of 269 nM. DAO is an enzyme responsible for D-serine metabolism, D-serine is a co-agonist of NMDA receptors[1].

 Names

Name 6h-thieno[2,3-b]pyrrole-5-carboxylic acid

 DAO-IN-1 Biological Activity

Description DAO-IN-1 is a potent inhibitor of D-amino acid oxidase (DAO) with an IC50 value of 269 nM. DAO is an enzyme responsible for D-serine metabolism, D-serine is a co-agonist of NMDA receptors[1].
Related Catalog
Target

D-amino acid oxidase (DAO)[1]

References

[1]. Sparey T, et al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3386-91.  

 Chemical & Physical Properties

Density 1.609 g/cm3
Boiling Point 437.4ºC at 760 mmHg
Molecular Formula C7H5NO2S
Molecular Weight 167.19
Flash Point 218.3ºC
Exact Mass 167.00400
PSA 81.33000
LogP 1.92760

 Safety Information

HS Code 2934999090

 Synthetic Route

ethyl 6H-thieno[2,3-b]pyrrole-5-carboxylate structure

ethyl 6H-thieno...

CAS#:35357-56-3

~100%

DAO-IN-1 Structure

DAO-IN-1

CAS#:51856-25-8

Literature: Keio University Patent: EP2022794 A1, 2009 ; Location in patent: Page/Page column 18; 19 ;
3-Thiophenecarboxaldehyde structure

3-Thiophenecarb...

CAS#:498-62-4

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DAO-IN-1 Structure

DAO-IN-1

CAS#:51856-25-8

Literature: Venable, Jennifer D.; Cai, Hui; Chai, Wenying; Dvorak, Curt A.; Grice, Cheryl A.; Jablonowski, Jill A.; Shah, Chandra R.; Kwok, Annette K.; Ly, Kiev S.; Pio, Barbara; Wei, Jianmei; Desai, Pragnya J.; Jiang, Wen; Nguyen, Steven; Ling, Ping; Wilson, Sandy J.; Dunford, Paul J.; Thurmond, Robin L.; Lovenberg, Timothy W.; Karlsson, Lars; Carruthers, Nicholas I.; Edwards, James P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8289 - 8298
Ethyl azido-3-thiopheneacrylate structure

Ethyl azido-3-t...

CAS#:335030-68-7

~%

DAO-IN-1 Structure

DAO-IN-1

CAS#:51856-25-8

Literature: Venable, Jennifer D.; Cai, Hui; Chai, Wenying; Dvorak, Curt A.; Grice, Cheryl A.; Jablonowski, Jill A.; Shah, Chandra R.; Kwok, Annette K.; Ly, Kiev S.; Pio, Barbara; Wei, Jianmei; Desai, Pragnya J.; Jiang, Wen; Nguyen, Steven; Ling, Ping; Wilson, Sandy J.; Dunford, Paul J.; Thurmond, Robin L.; Lovenberg, Timothy W.; Karlsson, Lars; Carruthers, Nicholas I.; Edwards, James P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8289 - 8298
Methyl6H-thieno[2,3-b]pyrrole-5-carboxylate structure

Methyl6H-thieno...

CAS#:118465-49-9

~%

DAO-IN-1 Structure

DAO-IN-1

CAS#:51856-25-8

Literature: Whittamore, Paul R.O.; Addie, Matthew S.; Bennett, Stuart N.L.; Birch, Alan M.; Butters, Michael; Godfrey, Linda; Kenny, Peter W.; Morley, Andrew D.; Murray, Paul M.; Oikonomakos, Nikos G.; Otterbein, Ludovic R.; Pannifer, Andrew D.; Parker, Jeremy S.; Readman, Kristy; Siedlecki, Pawel S.; Schofield, Paul; Stocker, Andy; Taylor, Melvyn J.; Townsend, Linda A.; Whalley, David P.; Whitehouse, Jennifer Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5567 - 5571
N-(3-formylthiophen-2-yl)acetamide structure

N-(3-formylthio...

CAS#:41405-96-3

~%

DAO-IN-1 Structure

DAO-IN-1

CAS#:51856-25-8

Literature: Whittamore, Paul R.O.; Addie, Matthew S.; Bennett, Stuart N.L.; Birch, Alan M.; Butters, Michael; Godfrey, Linda; Kenny, Peter W.; Morley, Andrew D.; Murray, Paul M.; Oikonomakos, Nikos G.; Otterbein, Ludovic R.; Pannifer, Andrew D.; Parker, Jeremy S.; Readman, Kristy; Siedlecki, Pawel S.; Schofield, Paul; Stocker, Andy; Taylor, Melvyn J.; Townsend, Linda A.; Whalley, David P.; Whitehouse, Jennifer Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5567 - 5571

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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