Pipemidic acid

Modify Date: 2024-01-02 02:03:45

Pipemidic acid Structure
Pipemidic acid structure
 Common Name Pipemidic acid
CAS Number 51940-44-4 Molecular Weight 303.316
Density 1.4±0.1 g/cm3 Boiling Point 534.9±60.0 °C at 760 mmHg
Molecular Formula C14H17N5O3 Melting Point 251-255℃
MSDS Chinese USA Flash Point 277.3±32.9 °C
Symbol GHS08
GHS08		 Signal Word Danger

 Use of Pipemidic acid


Pipemidic scid is a new antibacterial agent, is active against Pseudomonas aeruginosa.

 Names

Name pipemidic acid
Synonym More Synonyms

 Pipemidic acid Biological Activity

Description Pipemidic scid is a new antibacterial agent, is active against Pseudomonas aeruginosa.
Related Catalog

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 534.9±60.0 °C at 760 mmHg
Melting Point 251-255℃
Molecular Formula C14H17N5O3
Molecular Weight 303.316
Flash Point 277.3±32.9 °C
Exact Mass 303.133148
PSA 100.35000
LogP -0.16
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.617

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1153800
CHEMICAL NAME :
Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-8-ethyl-5-oxo-2-(1-piperazinyl)-
CAS REGISTRY NUMBER :
51940-44-4
LAST UPDATED :
199612
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C14-H17-N5-O3
MOLECULAR WEIGHT :
303.36
WISWESSER LINE NOTATION :
T66 BN DN GV JNJ HVQ J2 C- DT6M DNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1438 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
529 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1213 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
90 gm/kg/30D-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Liver - changes in liver weight Endocrine - changes in thymus weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 mg/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22400 mg/kg
SEX/DURATION :
female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1400 mg/kg
SEX/DURATION :
female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22400 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 20 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
152 mg/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,397,1988

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H317-H334
Precautionary Statements P261-P280-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi
Risk Phrases 42/43
Safety Phrases 22-36/37-45
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS UV1153800

 Synthetic Route

Ethyl 8-Ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate (Pipemidic Acid Ethyl Ester) structure

Ethyl 8-Ethyl-5...

CAS#:51940-43-3

~%

Pipemidic acid Structure

Pipemidic acid

CAS#:51940-44-4

Literature: Dainippon Pharmaceutical Co., Ltd. Patent: US3962443 A1, 1976 ;
N/A structure

N/A

CAS#:52070-73-2

~%

Pipemidic acid Structure

Pipemidic acid

CAS#:51940-44-4

Literature: Dainippon Pharmaceutical Co., Ltd. Patent: US3962443 A1, 1976 ;
Piperazine Hexahydrate structure

Piperazine Hexa...

CAS#:142-63-2

2-Methylmercapto-5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)-pyrimidine-6-carboxylic acid structure

2-Methylmercapt...

CAS#:19572-11-3

~%

Pipemidic acid Structure

Pipemidic acid

CAS#:51940-44-4

Literature: Dainippon Pharmaceutical Co., Ltd. Patent: US3962443 A1, 1976 ;
Diethyl sulfate structure

Diethyl sulfate

CAS#:64-67-5

pipemidic acid structure

pipemidic acid

CAS#:52070-56-1

~%

Pipemidic acid Structure

Pipemidic acid

CAS#:51940-44-4

N/A structure

N/A

CAS#:51940-55-7

Literature: Dainippon Pharmaceutical Co., Ltd. Patent: US3962443 A1, 1976 ;

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 Synonyms

Piperamic Acid
Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-
EINECS 257-530-2
Pipemidic acid
Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-
8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid
MFCD00057291
8-Ethyl-5-oxo-2-(1-piperazinyl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidine-6-carboxylic Acid
8-ethyl-5-oxo-2-piperazin-1-yl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid
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Chemsrc provides Pipemidic acid(CAS#:51940-44-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Pipemidic acid are included as well.>> amp version: Pipemidic acid

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