L-(+)-Penicillamine
L-(+)-Penicillamine structure
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Common Name | L-(+)-Penicillamine | ||
|---|---|---|---|---|
| CAS Number | 52-66-4 | Molecular Weight | 149.211 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 251.8±35.0 °C at 760 mmHg | |
| Molecular Formula | C5H11NO2S | Melting Point | 208-212ºC | |
| MSDS | Chinese USA | Flash Point | 106.1±25.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of L-(+)-PenicillamineDL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response[1][2][3]. |
| Name | penicillamine |
|---|---|
| Synonym | More Synonyms |
| Description | DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response[1][2][3]. |
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| Related Catalog | |
| In Vivo | DL-Penicillamine (25 mg/kg; i.p.; twice daily, for 5 days) has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A)[2]. Animal Model: Male Wistar rats, NIH strain (intoxicated by i.p. injection of 32 mg/kg thallium (I) acetate)[2] Dosage: 25 mg/kg Administration: i.p.; twice daily, for 5 days Result: Decreased slightly the thallium content in blood, organs and brain. Increased the probability survival when co-treated with Prussian blue (50 mg/kg; p.o.). |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 251.8±35.0 °C at 760 mmHg |
| Melting Point | 208-212ºC |
| Molecular Formula | C5H11NO2S |
| Molecular Weight | 149.211 |
| Flash Point | 106.1±25.9 °C |
| Exact Mass | 149.051056 |
| PSA | 102.12000 |
| LogP | 0.93 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.528 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S26;S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | YV9445000 |
| HS Code | 2930909090 |
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L-(+)-Penicillamine CAS#:52-66-4 |
| Literature: Nakajima, Suanne; Zhenwei, Miao; Sun, Ying; Tang, Datong; Xu, Guoyou; Porter, Brian; Or, Yat Sun; Wang, Zhe Patent: US2004/266668 A1, 2004 ; Location in patent: Page/Page column 56 ; |
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L-(+)-Penicillamine CAS#:52-66-4 |
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Literature: Tatsuoka; Miyamoto Yakugaku Zasshi, 1949 , vol. 69, p. 294,297 Chem.Abstr., 1950 , p. 2513 Full Text Show Details Leach; Hunter Biochemical Preparations, 1953 , vol. 3, p. 111,114 Anm. 7 Full Text Show Details Crooks Chem.Penicillin, |
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L-(+)-Penicillamine CAS#:52-66-4 |
| Literature: Tatsuoka; Miyamoto Yakugaku Zasshi, 1949 , vol. 69, p. 294,297 Chem.Abstr., 1950 , p. 2513 |
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L-(+)-Penicillamine CAS#:52-66-4 |
| Literature: Munro, Andrew P.; Williams, D. Lyn H. Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 9 p. 1794 - 1797 |
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L-(+)-Penicillamine CAS#:52-66-4 |
| Literature: Kessler, David P.; Ghebre-Sellassie, Isaac; Knevel, Adelbert M.; Hem, Stanley L. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1981 , p. 1247 - 1251 |
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L-(+)-Penicillamine CAS#:52-66-4 |
| Literature: Schaefer, K.; Asmus, K.-D. Journal of Physical Chemistry, 1981 , vol. 85, # 7 p. 852 - 855 |
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L-(+)-Penicillamine CAS#:52-66-4 |
| Literature: Merck and Co. Inc. Patent: US2516240 , 1946 ; |
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L-(+)-Penicillamine CAS#:52-66-4 |
| Literature: Holmes, Anthony J.; Williams, D. Lyn H. Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 8 p. 1639 - 1644 |
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L-(+)-Penicillamine CAS#:52-66-4 |
| Literature: Surdhar, Parminder S.; Mezyk, Stephen P.; Armstrong, David A. Journal of Physical Chemistry, 1989 , vol. 93, # 8 p. 3360 - 3363 |
| Precursor 8 | |
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| DownStream 10 | |
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CAS#:117918-23-7| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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