Amentoflavone-4',4",7-trimethyl Ether

Modify Date: 2024-01-05 18:27:35

Amentoflavone-4',4",7-trimethyl Ether Structure
Amentoflavone-4',4",7-trimethyl Ether structure
 Common Name Amentoflavone-4',4",7-trimethyl Ether
CAS Number 521-34-6 Molecular Weight 580.538
Density 1.4±0.1 g/cm3 Boiling Point 839.6±65.0 °C at 760 mmHg
Molecular Formula C33H24O10 Melting Point 296-298ºC
MSDS N/A Flash Point 276.2±27.8 °C

 Use of Amentoflavone-4',4",7-trimethyl Ether


Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].

 Names

Name sciadopitysin
Synonym More Synonyms

 Amentoflavone-4',4",7-trimethyl Ether Biological Activity

Description Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].
Related Catalog
Target

NF-κB

In Vitro Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1[2].
In Vivo Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2].
References

[1]. Briançon-Scheid F, et al. HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba. Planta Med. 1983 Dec;49(12):204-7.

[2]. Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents boneloss in LPS-treated mice. Int Immunopharmacol. 2017 Aug;49:109-117. 

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 839.6±65.0 °C at 760 mmHg
Melting Point 296-298ºC
Molecular Formula C33H24O10
Molecular Weight 580.538
Flash Point 276.2±27.8 °C
Exact Mass 580.136963
PSA 148.80000
LogP 5.50
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.684

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25
HS Code 29329990

 Synonyms

Amentoflavone-4',4",7-trimethyl Ether
I-7,I-4',II-4'-tri-O-methylamentoflavone
Amentoflavone-7,4',4'''-trimethyl ether
5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-chromen-4-one
Sciadopitysin
5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-
Sciadopytissin
Jin Song biflavone
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