- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Amentoflavone-4',4",7-trimethyl Ether
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- BioBioPha
- China
- Product Name: Amentoflavone-4',4",7-trimethyl Ether
- Price: ￥Inquiry/5mg
- Purity: 96.0%
- Stocking Period: 10 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Amentoflavone-4',4",7-trimethyl Ether
- Price: ￥1440.0/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Sciadopitysin
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
521-34-6
521-34-6 structure
- Name: Amentoflavone-4',4",7-trimethyl Ether
- Chemical Name: sciadopitysin
- CAS Number: 521-34-6
- Molecular Formula: C33H24O10
- Molecular Weight: 580.538
- Catalog: Natural product Flavonoids
- Create Date: 2018-07-13 16:28:11
- Modify Date: 2024-01-05 18:27:35
-
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].
| Name | sciadopitysin |
|---|---|
| Synonyms |
Amentoflavone-4',4",7-trimethyl Ether
I-7,I-4',II-4'-tri-O-methylamentoflavone Amentoflavone-7,4',4'''-trimethyl ether 5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-chromen-4-one Sciadopitysin 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)- Sciadopytissin Jin Song biflavone |
| Description | Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2]. |
|---|---|
| Related Catalog | |
| Target |
NF-κB |
| In Vitro | Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1[2]. |
| In Vivo | Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 839.6±65.0 °C at 760 mmHg |
| Melting Point | 296-298ºC |
| Molecular Formula | C33H24O10 |
| Molecular Weight | 580.538 |
| Flash Point | 276.2±27.8 °C |
| Exact Mass | 580.136963 |
| PSA | 148.80000 |
| LogP | 5.50 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.684 |
|
~95%
521-34-6 |
| Literature: Muller, Dominique; Fleury, Jean-Pierre Tetrahedron Letters, 1991 , vol. 32, # 20 p. 2229 - 2232 |
|
~%
521-34-6 |
| Literature: Muller, Dominique; Fleury, Jean-Pierre Tetrahedron Letters, 1991 , vol. 32, # 20 p. 2229 - 2232 |
|
~%
521-34-6 |
| Literature: Muller, Dominique; Fleury, Jean-Pierre Tetrahedron Letters, 1991 , vol. 32, # 20 p. 2229 - 2232 |
| Precursor 2 | |
|---|---|
| DownStream 3 | |
![3-[5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-8-yl]-4-methoxybenzoic acid structure](https://image.chemsrc.com/caspic/241/438051-00-4.png)
