Tetramethylcurcumin

Modify Date: 2024-01-03 20:27:00

Tetramethylcurcumin structure	Common Name	Tetramethylcurcumin
	CAS Number	52328-97-9	Molecular Weight	424.486
	Density	1.1±0.1 g/cm3	Boiling Point	594.5±50.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₈O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	255.1±30.2 °C

Use of Tetramethylcurcumin

Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].

Name	(1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione
Synonym	More Synonyms

Description	Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Inflammation/Immunology
Target	STAT3
In Vitro	Tetramethylcurcumin (FLLL31; 2.5 and 5 µM; for 24 hours) downregulats STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells[1]. Tetramethylcurcumin inhibits cell viability, cell invasion. Tetramethylcurcumin is a effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines[1].
References	[1]. Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010 Mar 15;70(6):2445-54. [2]. Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol. 2014 Jul;21(1):128-36.

Density	1.1±0.1 g/cm3
Boiling Point	594.5±50.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₈O₆
Molecular Weight	424.486
Flash Point	255.1±30.2 °C
Exact Mass	424.188599
PSA	71.06000
LogP	4.81
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.575

Tetramethylcurcumin MSDS(Chinese)

Hazard Statements	H413
Hazard Codes	N
RIDADR	NONH for all modes of transport

Dimethoxycurcumin

CAS#:160096-59-3

methyl iodide

CAS#:74-88-4

~78%

Tetramethylcurcumin

CAS#:52328-97-9

Literature: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION; LI, Pui-Kai; LI, Chenglong; LIN, Jiayuh; FUCHS, James, R. Patent: WO2010/121007 A1, 2010 ; Location in patent: Page/Page column 5; 14-15 ;

2,4-Pentandione

CAS#:123-54-6

Tetramethylcurcumin

CAS#:52328-97-9

Literature: Bayomi, Said M.; El-Kashef, Hassan A.; El-Ashmawy, Mahmoud B.; Nasr, Magda N. A.; El-Sherbeny, Magda A.; Badria, Farid A.; Abou-Zeid, Laila A.; Ghaly, Mariam A.; Abdel-Aziz, Naglaa I. Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1147 - 1162

2,4-Pentanedion...

CAS#:3142-58-3

veratraldehyde

CAS#:120-14-9

Tetramethylcurcumin

CAS#:52328-97-9

Precursor 5
CAS#:160096-59-3 Dimethoxycurcumin CAS#:74-88-4 methyl iodide CAS#:123-54-6 2,4-Pentandione CAS#:3142-58-3 2,4-Pentanedion...
CAS#:120-14-9 veratraldehyde
DownStream 0

Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment.

Cell Physiol. Biochem. 36 , 2340-56, (2015)

Interleukin-17 (IL-17) is a major pro-inflammatory cytokine that initiates and maintains inflammation. However, the molecular mechanisms as to how IL-17 influences endothelial cells to promote neutrop...

Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells.

PLoS ONE 10(3) , e0119857, (2015)

Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most co...

Effect of LIF-withdrawal on acetylcholine synthesis in the embryonic stem cell line CGR8 is not mediated by STAT3, PI3Ks or cAMP/PKA pathways.

Int. Immunopharmacol. 29 , 115-8, (2015)

Acetylcholine (ACh) acts as a local cellular signaling molecule and is widely expressed in nature, including mammalian cells and embryonic stem cells. The murine embryonic stem cell line CGR8 synthesi...

FLLL31

(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione

Tetramethylcurcumin

(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tetramethylcurcumin
Price: Click To Check
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tetramethylcurcumin
Price: ￥1478.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: FLLL31
Price: $600.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: FLLL31
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Tetramethylcurcumin

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