Dauricine

Modify Date: 2024-01-01 21:44:51

Dauricine structure	Common Name	Dauricine
	CAS Number	524-17-4	Molecular Weight	624.766
	Density	1.2±0.1 g/cm3	Boiling Point	712.3±60.0 °C at 760 mmHg
	Molecular Formula	C₃₈H₄₄N₂O₆	Melting Point	115ºC
	MSDS	N/A	Flash Point	384.6±32.9 °C

Use of Dauricine

Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer[1].

Name	dauricine
Synonym	More Synonyms

Description	Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology
References	[1]. Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75.

Density	1.2±0.1 g/cm3
Boiling Point	712.3±60.0 °C at 760 mmHg
Melting Point	115ºC
Molecular Formula	C₃₈H₄₄N₂O₆
Molecular Weight	624.766
Flash Point	384.6±32.9 °C
Exact Mass	624.319946
PSA	72.86000
LogP	6.61
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.601
Storage condition	2-8 °C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM9490000

CHEMICAL NAME :: Phenol, 4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoqu inolinyl)methyl)-2-(4 -((1,2,3,4- tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)met hyl)phenoxy)-, (R-(R*,R*))-

CAS REGISTRY NUMBER :: 524-17-4

LAST UPDATED :: 198906

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C38-H44-N2-O6

MOLECULAR WEIGHT :: 624.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,182,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,419,1986

Hazard Codes	Xi

[R-(R*,R*)]-4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]-2-[4-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]phenol

Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]-

6,6'-Di-O-Methyldauricoline

4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-(4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenoxy)phenol

4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-2-(4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}phenoxy)phenol

Dauricine

Dauricine (8CI)

Menispermum dauricum DC Extract

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Dauricine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Dauricine
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dauricine
Price: ￥1488.0/20mg ￥788.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Dauricine
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Dauricine

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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