Fraxin

Modify Date: 2024-01-02 20:00:22

Fraxin Structure
Fraxin structure
 Common Name Fraxin
CAS Number 524-30-1 Molecular Weight 370.308
Density 1.6±0.1 g/cm3 Boiling Point 722.2±60.0 °C at 760 mmHg
Molecular Formula C16H18O10 Melting Point 205-208ºC
MSDS Chinese USA Flash Point 267.1±26.4 °C

 Use of Fraxin


Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2].

 Names

Name fraxin
Synonym More Synonyms

 Fraxin Biological Activity

Description Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2].
Related Catalog
Target

Cyclo AMP phosphodiesterase enzyme[2].

In Vitro Fraxin (100 μM) is non-cytotoxic on Hep G2 cells. Fraxin at non-cytotoxic concentrations significantly decreases the t-BHP-induced ROS generation in a dose-dependent manner[1]. Fraxin (0.5 mM) shows free radical scavenging effect at high concentration and cell protective effect against H2O2-mediated oxidative stress[2].
In Vivo Fraxin (50 mg/kg, p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl4-treated group[1].
References

[1]. Fraxin (50 mg/kg, p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl4-treated group[1].

[2]. Whang WK, et al. Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp Mol Med. 2005 Oct 31;37(5):436-46.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 722.2±60.0 °C at 760 mmHg
Melting Point 205-208ºC
Molecular Formula C16H18O10
Molecular Weight 370.308
Flash Point 267.1±26.4 °C
Exact Mass 370.089996
PSA 159.05000
LogP -1.93
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.664
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS DJ3091000

 Precursor & DownStream

Precursor  0

DownStream  1

 Articles12

More Articles
Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.

J. Med. Microbiol. 60(Pt 12) , 1827-34, (2011)

The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six of 46 active components fou...

[Studies on chemical constituents from stem barks of Fraxinus paxiana].

Zhongguo Zhong Yao Za Zhi 33(16) , 1990-3, (2008)

To investigate the chemical constituents of Fraxinus paxiana.The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with...

[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].

Zhongguo Zhong Yao Za Zhi 33(14) , 1708-10, (2008)

To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity.The chemical constituents were isolated and purified by chromatographic tech...

 Synonyms

7,8-Dihydroxy-6-methoxycoumarin-8-b-D-glucoside
7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl β-D-glucopyranoside
8-(Glucosyloxy)-6-methoxyumbelliferone
UNII-V7M270Y072
2H-1-Benzopyran-2-one, 8-(β-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-
7-Hydroxy-6-méthoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-2H-chromén-2-one
7-Hydroxy-6-methoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-on
8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one
Fraxin
8-(b-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one
Fraxoside
Fraxetin-8-O-glucoside
Fraxetin-8-glucoside
Paviin
7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl-β-D-glucopyranoside
Fraxetol 8-glucoside
7-Hydroxy-6-methoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-one
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Fraxin suppliers

Price: ￥900/5 mg

Reference only. check more Fraxin price

Related Compounds: More...
fraxin-8-O-β-D-glucopyranoside
58970-71-1
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
3-[2-(Aminooxy)ethyl]-4-bromophenol
1891956-25-4
10,13-Dimethyl-3,11-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
80699-76-9
7-Bromo-2-phenyl-5H-oxazolo[5,4-b]carbazole
1792994-02-5
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
3,6-dichloro-5-(difluoromethyl)pyridin-2-amine
1806819-30-6
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
Chemsrc provides Fraxin(CAS#:524-30-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Fraxin are included as well.>> amp version: Fraxin

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved