Calcimycin

Modify Date: 2024-01-03 16:42:03

Calcimycin structure	Common Name	Calcimycin
	CAS Number	52665-69-7	Molecular Weight	523.621
	Density	1.3±0.1 g/cm3	Boiling Point	710.3±55.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₃₇N₃O₆	Melting Point	187-190 °C
	MSDS	USA	Flash Point	383.4±31.5 °C

Use of Calcimycin

Calcimycin (A23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation of mammalian cells. It induces apoptosis[1][2][3][4].

Name	ionophore A23187
Synonym	More Synonyms

Description	Calcimycin (A23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation of mammalian cells. It induces apoptosis[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82. [2]. Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94. [3]. Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90. [4]. Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Autophagy >> Autophagy

References

[1]. Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82.

[2]. Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94.

[3]. Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90.

[4]. Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200.

Density	1.3±0.1 g/cm3
Boiling Point	710.3±55.0 °C at 760 mmHg
Melting Point	187-190 °C
Molecular Formula	C₂₉H₃₇N₃O₆
Molecular Weight	523.621
Flash Point	383.4±31.5 °C
Exact Mass	523.268250
PSA	126.68000
LogP	5.66
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.611
Storage condition	2-8°C

Calcimycin MSDS(Chinese)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38-20/21/22
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DM4676000
HS Code	29349990

Precursor 7
CAS#:58288-38-3 (-)-calcimycin ... CAS#:78024-03-0 1-(1-tert-butyl... CAS#:86214-09-7 (2R,3R,6S,8S,9R... CAS#:81550-83-6 methyl 3-hydrox...
CAS#:100845-53-2 (2R,3R,6S,8S,9R... CAS#:80657-88-1 (2R,4R)-2-methy... CAS#:79558-78-4 (2S,4S)-2-methy...
DownStream 0

[Characterisation of enucleated cells apoptosis: human platelets and erythrocytes].

Ross. Fiziol. Zh. Im. I. M. Sechenova 99(1) , 92-110, (2013)

Apoptosis is a common mechanism of programmed cell death in virtually all nucleated cells. In spite of the fact that platelets and erythrocytes are the only enucleated cells in mammals they contain mo...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.

Mol. Pharmacol. 87(3) , 451-64, (2015)

We have previously reported that curcumin analogs with a C7 linker bearing a C4-C5 olefinic linker with a single keto group at C3 (enone linker) display midnanomolar activity against the bloodstream f...

Ethacrynic acid-d5

4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-

MFCD00151202

CALCIUM PHOSPHINATE

Lime hypophosphite

CALCIUMHYPOPHOSPHITE,PURIFIED

CALCIUM HYPOPHOSPHITE TECHNICAL

CALCIUM HYPOPHOSPHITE EXTRA PURE,DAC

5-(Methylamino)-2-({(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)-2-propanyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid

ANTIBIOTIC A 23187

Phosphinicacid,calciumsalt

Calcium bisphosphinate

5-(Methylamino)-2-({(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(2R)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid

Calcium hydrophosphite

EINECS 258-084-1

6S-[6a(2S*,3S*),8b(R*),9b,11a]-5-(Methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic Acid

Calcimycin

A23187,free acid