Hydroxyecdysone

Modify Date: 2024-01-01 20:42:54

Hydroxyecdysone structure	Common Name	Hydroxyecdysone
	CAS Number	5289-74-7	Molecular Weight	480.634
	Density	1.3±0.1 g/cm3	Boiling Point	702.1±60.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₄O₇	Melting Point	242-244 °C
	MSDS	Chinese USA	Flash Point	392.4±29.4 °C

Use of Hydroxyecdysone

Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1].Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2].

Name	20-hydroxyecdysone
Synonym	More Synonyms

Description	Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1].Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9. [2]. Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Apoptosis >> Caspase

Signaling Pathways >> Autophagy >> Autophagy

References

[1]. Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9.

[2]. Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84.

Density	1.3±0.1 g/cm3
Boiling Point	702.1±60.0 °C at 760 mmHg
Melting Point	242-244 °C
Molecular Formula	C₂₇H₄₄O₇
Molecular Weight	480.634
Flash Point	392.4±29.4 °C
Exact Mass	480.308716
PSA	138.45000
LogP	-0.53
Vapour Pressure	0.0±5.0 mmHg at 25°C
Index of Refraction	1.597
Storage condition	2-8°C
Water Solubility	alcohol: soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ8060000

CHEMICAL NAME :: 5-beta-Cholest-7-en-6-one, 2-beta,3-beta,14,20,22,25-hexahydroxy-, (22R)-

CAS REGISTRY NUMBER :: 5289-74-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C27-H44-O7

MOLECULAR WEIGHT :: 480.71

WISWESSER LINE NOTATION :: L E5 B666 LV JUTJ A1 E1 FXQ1&YQ2XQ1&1 IQ OQ PQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 350 ug/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 100 nmol/L

REFERENCE :: ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72. Volume(issue)/page/year: 41,183,1971

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	FZ8060000
Packaging Group	II; III
Hazard Class	4.1
HS Code	2937290090

HS Code	2937290090

Functions of nuclear receptor HR3 during larval-pupal molting in Leptinotarsa decemlineata (Say) revealed by in vivo RNA interference.

Insect Biochem. Mol. Biol. 63 , 23-33, (2015)

Our previous results revealed that RNA interference-aided knockdown of Leptinotarsa decemlineata FTZ-F1 (LdFTZ-F1) reduced 20E titer, and impaired pupation. In this study, we characterized a putative ...

Identification of two juvenile hormone inducible transcription factors from the silkworm, Bombyx mori.

J. Insect Physiol. 80 , 31-41, (2015)

Juvenile hormone (JH) regulates many physiological processes in insects. However, the signal cascades in which JH is active have not yet been fully elucidated, particularly in comparison to another ma...

A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila.

Nucleic Acids Res. 42(16) , 10409-24, (2014)

The early genes are a key group of ecdysone targets that function at the top of the signaling hierarchy. In the presence of ecdysone, early genes exhibit a highly characteristic rapid and powerful ind...

CRUSTECDYSONE

20-hydroxyecdysone

MFCD00036740

(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-Trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methyl-2-heptanyl]-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-on

β-ecdysone

(2β,3β,5β,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one

Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2β,3β,5β,22R)-

Hydroxyecdysone

b-Ecdysone

Isoinokosterone

Commisterone

(2b,3b,5b,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one

Ecdysterone

(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-Trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methyl-2-heptanyl]-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-one

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Product Name: Beta-Ecdysterone
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