Euparin

Modify Date: 2024-01-04 00:41:05

Euparin Structure
Euparin structure
 Common Name Euparin
CAS Number 532-48-9 Molecular Weight 216.23300
Density 1.187g/cm3 Boiling Point 258.3ºC at 760mmHg
Molecular Formula C13H12O3 Melting Point 152-153℃
MSDS N/A Flash Point 110ºC

 Use of Euparin


Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2].

 Names

Name 1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone
Synonym More Synonyms

 Euparin Biological Activity

Description Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2].
Related Catalog
In Vitro In Vero cells, Euparin shows antiviral activity against poliovirus types 1, 2, and 3 with EC50 values of 0.47 µg/mL, 0.12 µg/mL, and 0.15 µg/mL, respectively[1].
In Vivo Euparin (8, 16 and 32 mg/kg) reduces depression-like behavior in Chronic Unpredictable Mild Stress (CUMS) model of mice. All doses of Euparin are found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ROS) levels in brain of depression mice. Euparin restores CUMS-induced decrease of Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), N-methyl-D-aspartate receptor subtype 2B (NMDAR2B) and brain derived neurotrophic factor (BDNF) expression[2].
References

[1]. aría Florencia Visintini Jaime, et al. Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound. Evid Based Complement Alternat Med. 2013;2013:402364.

[2]. Xu-Meng Han, et al. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biol Pharm Bull. 2020 Oct 1;43(10):1490-1500.

 Chemical & Physical Properties

Density 1.187g/cm3
Boiling Point 258.3ºC at 760mmHg
Melting Point 152-153℃
Molecular Formula C13H12O3
Molecular Weight 216.23300
Flash Point 110ºC
Exact Mass 216.07900
PSA 50.44000
LogP 3.37410
Index of Refraction 1.602

 Safety Information

Hazard Codes Xi
HS Code 2932999099

 Synthetic Route

5-Acetyl-6-hydroxy-2-(1-hydroxy-1-methylethyl)benzofuran structure

5-Acetyl-6-hydr...

CAS#:173992-05-7

~83%

Euparin Structure

Euparin

CAS#:532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
2,4-Dihydroxyacetophenone structure

2,4-Dihydroxyac...

CAS#:89-84-9

~%

Euparin Structure

Euparin

CAS#:532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
1-(2,4-bis(benzyloxy)phenyl)ethanone structure

1-(2,4-bis(benz...

CAS#:22877-01-6

~%

Euparin Structure

Euparin

CAS#:532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
1-(2,4-dihydroxy-5-iodophenyl)ethanone structure

1-(2,4-dihydrox...

CAS#:62069-33-4

~%

Euparin Structure

Euparin

CAS#:532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
5'-iodo-2',4'-bis(tosyloxy)acetophenone structure

5'-iodo-2',4'-b...

CAS#:173992-03-5

~%

Euparin Structure

Euparin

CAS#:532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
5'-(3-hydroxy-3-methylbutynyl)-2',4'-bis(tosyloxy)acetophenone structure

5'-(3-hydroxy-3...

CAS#:173992-04-6

~%

Euparin Structure

Euparin

CAS#:532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
1-(2,4-dihydroxy-3,5-diiodophenyl)ethanone structure

1-(2,4-dihydrox...

CAS#:62069-34-5

~%

Euparin Structure

Euparin

CAS#:532-48-9

Literature: Scannell, Ralph T.; Stevenson, Robert Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2927 - 2932
1-(2,4-dihydroxy-5-iodophenyl)ethanone structure

1-(2,4-dihydrox...

CAS#:62069-33-4

copper(1+),2-methylbut-1-en-3-yne structure

copper(1+),2-me...

CAS#:56964-06-8

~32%

Euparin Structure

Euparin

CAS#:532-48-9

Literature: Scannell, Ralph T.; Stevenson, Robert Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2927 - 2932

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1-(6-Hydroxy-2-isopropenyl-benzofuran-5-yl)-aethanon
5-acetyl-6-hydroxy-2-isopropenylbenzofuran
1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone
1-[6-hydroxy-2-(1-methylethenyl)-5-benzofuranyl]-ethanone
Euparin
1-(6-hydroxy-2-isopropenyl-benzofuran-5-yl)-ethanone
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Chemsrc provides Euparin(CAS#:532-48-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Euparin are included as well.>> amp version: Euparin

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