532-48-9
532-48-9 structure
- Name: Euparin
- Chemical Name: 1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone
- CAS Number: 532-48-9
- Molecular Formula: C13H12O3
- Molecular Weight: 216.23300
- Catalog: Natural product Phenols
- Create Date: 2018-05-18 08:00:00
- Modify Date: 2024-01-04 00:41:05
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Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2].
| Name | 1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone |
|---|---|
| Synonyms |
1-(6-Hydroxy-2-isopropenyl-benzofuran-5-yl)-aethanon
5-acetyl-6-hydroxy-2-isopropenylbenzofuran 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone 1-[6-hydroxy-2-(1-methylethenyl)-5-benzofuranyl]-ethanone Euparin 1-(6-hydroxy-2-isopropenyl-benzofuran-5-yl)-ethanone |
| Description | Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | In Vero cells, Euparin shows antiviral activity against poliovirus types 1, 2, and 3 with EC50 values of 0.47 µg/mL, 0.12 µg/mL, and 0.15 µg/mL, respectively[1]. |
| In Vivo | Euparin (8, 16 and 32 mg/kg) reduces depression-like behavior in Chronic Unpredictable Mild Stress (CUMS) model of mice. All doses of Euparin are found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ROS) levels in brain of depression mice. Euparin restores CUMS-induced decrease of Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), N-methyl-D-aspartate receptor subtype 2B (NMDAR2B) and brain derived neurotrophic factor (BDNF) expression[2]. |
| References |
| Density | 1.187g/cm3 |
|---|---|
| Boiling Point | 258.3ºC at 760mmHg |
| Melting Point | 152-153℃ |
| Molecular Formula | C13H12O3 |
| Molecular Weight | 216.23300 |
| Flash Point | 110ºC |
| Exact Mass | 216.07900 |
| PSA | 50.44000 |
| LogP | 3.37410 |
| Index of Refraction | 1.602 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2932999099 |
| Precursor 6 | |
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| DownStream 1 | |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |