Coixol

Modify Date: 2024-01-07 16:56:52

Coixol structure	Common Name	Coixol
	CAS Number	532-91-2	Molecular Weight	165.146
	Density	1.3±0.1 g/cm3	Boiling Point	292.97°C (rough estimate)
	Molecular Formula	C₈H₇NO₃	Melting Point	151-156ºC(lit.)
	MSDS	N/A	Flash Point	N/A

Use of Coixol

Coixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen.IC50 value:Target:In vitro: Confluent NCI-H292 cells were pretreated with oleic acid, linoleic acid, glyceryl trilinoleate, beta-stigmasterol or coixol for 30 min and then stimulated with PMA (phorbol 12-myristate 13-acetate), EGF (epidermal growth factor) or TNF-α (tumor necrosis factor-α) for 24 h. Coixol inhibited the expression of MUC5AC mucin gene and production of MUC5AC mucin protein, induced by EGF or TNF-α from NCI-H292 cells; Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells [1]. βTC-6 cells were incubated in 2 mM and 20 mM glucose in thepresence of coixol (200 μM) for 60 min at 37°C in Krebs-RingerBicarbonate buffer. Decreased insulin staining was observed by coixol at 20 mM glucose (bottom) suggest that coixol stimulated insulin secretion at high glucose concentration [2].In vivo:

Name	6-methoxy-2-benzoxazolinone
Synonym	More Synonyms

Description	Coixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen.IC50 value:Target:In vitro: Confluent NCI-H292 cells were pretreated with oleic acid, linoleic acid, glyceryl trilinoleate, beta-stigmasterol or coixol for 30 min and then stimulated with PMA (phorbol 12-myristate 13-acetate), EGF (epidermal growth factor) or TNF-α (tumor necrosis factor-α) for 24 h. Coixol inhibited the expression of MUC5AC mucin gene and production of MUC5AC mucin protein, induced by EGF or TNF-α from NCI-H292 cells; Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells [1]. βTC-6 cells were incubated in 2 mM and 20 mM glucose in thepresence of coixol (200 μM) for 60 min at 37°C in Krebs-RingerBicarbonate buffer. Decreased insulin staining was observed by coixol at 20 mM glucose (bottom) suggest that coixol stimulated insulin secretion at high glucose concentration [2].In vivo:
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Others
References	[1]. Lee HJ, et al. Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin. Arch Pharm Res. 2015;38(5):620-7. [2]. Rahman M Hafizur, et al. Coixol Exerts an Exclusive Glucose-dependent Insulinotropic Effect in βTC-6Cells. Hafizur et al., J Cytol Histol 2015, 6:3

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Others

References

[1]. Lee HJ, et al. Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin. Arch Pharm Res. 2015;38(5):620-7.

[2]. Rahman M Hafizur, et al. Coixol Exerts an Exclusive Glucose-dependent Insulinotropic Effect in βTC-6Cells. Hafizur et al., J Cytol Histol 2015, 6:3

Density	1.3±0.1 g/cm3
Boiling Point	292.97°C (rough estimate)
Melting Point	151-156ºC(lit.)
Molecular Formula	C₈H₇NO₃
Molecular Weight	165.146
Exact Mass	165.042587
PSA	55.23000
LogP	1.07
Appearance of Characters	light tan
Index of Refraction	1.563
Storage condition	2-8°C

Coixol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM5275200

CHEMICAL NAME :: 2-Benzoxazolinone, 6-methoxy-

CAS REGISTRY NUMBER :: 532-91-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H7-N-O3

MOLECULAR WEIGHT :: 165.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 962 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 100 nmol/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,29,1976

Hazard Codes	Xi
Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	DM5275200
HS Code	2934999090

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