MEFLOQUINE structure
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Common Name | MEFLOQUINE | ||
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CAS Number | 53230-10-7 | Molecular Weight | 378.31200 | |
Density | 1.383g/cm3 | Boiling Point | 415.7ºC at 760mmHg | |
Molecular Formula | C17H16F6N2O | Melting Point | 242-244ºC | |
MSDS | N/A | Flash Point | 205.2ºC |
Use of MEFLOQUINEMefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research[1][2][3]. |
Name | mefloquine |
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Synonym | More Synonyms |
Description | Mefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research[1][2][3]. |
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Related Catalog | |
In Vitro | Mefloquine selectively inhibits prostate cancer (PCa) cell growth with an IC50 of ~10 μM. Mefloquine also induces hyperpolarization of the mitochondrial membrane potential (MMP), as well as ROS generation[2]. Mefloquine (10 μM)-mediated ROS simultaneously downregulated Akt phosphorylation and activated ERK, JNK and AMPK signaling in PC3 cells[2]. Mefloquine shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine in VeroE6/TMPRSS2 and Calu-3 cells, with IC50 of 1.28 μM, IC90 of 2.31 μM, and IC99 of 4.39 μM in VeroE6/TMPRSS2 cells. Mefloquine inhibits viral entry after viral attachment to the target cell[3]. |
In Vivo | Mefloquine (5 mg/kg; i.p.; daily; 14 days) reverses the lower vertebral cancellous bone volume and bone formation; and has modest effects on cortical bone volume, thickness, and moment of inertia in old mice[4]. |
References |
Density | 1.383g/cm3 |
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Boiling Point | 415.7ºC at 760mmHg |
Melting Point | 242-244ºC |
Molecular Formula | C17H16F6N2O |
Molecular Weight | 378.31200 |
Flash Point | 205.2ºC |
Exact Mass | 378.11700 |
PSA | 45.15000 |
LogP | 4.77670 |
Index of Refraction | 1.519 |
Storage condition | Refrigerator, Under Inert Atmosphere |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Pachycarpidine |
OXYMATRINE |
Kurainone |
matrine,1-oxide |
matrine n-oxide |
Oxymatrine std. |