[Ala11,D-Leu15]-Orexin B TFA

Modify Date: 2024-01-02 05:26:58

[Ala11,D-Leu15]-Orexin B TFA Structure
[Ala11,D-Leu15]-Orexin B TFA structure
 Common Name [Ala11,D-Leu15]-Orexin B TFA
CAS Number 532932-99-3 Molecular Weight 2857.258
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C120H206N44O35S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of [Ala11,D-Leu15]-Orexin B TFA


[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM)[1].

 Names

Name [Ala11,D-Leu15]-Orexin B
Synonym More Synonyms

 [Ala11,D-Leu15]-Orexin B TFA Biological Activity

Description [Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM)[1].
Related Catalog
Target

OX2:0.13 nM (EC50)

OX1:52 nM (EC50)

References

[1]. Asahi S, et al. Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. Bioorg Med Chem Lett. 2003;13(1):111-113.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C120H206N44O35S
Molecular Weight 2857.258
Exact Mass 2855.541260
PSA 1309.96000
LogP -10.70
Index of Refraction 1.670

 Synonyms

L-Methioninamide, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-D-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-ALA-GLN-ARG-LEU-D-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
M.W. 2857.28 C120H206N44O35S
L-Arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide
(Ala11,D-Leu15)-Orexin B (human)
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