1,3,5-Trihydroxy-4-prenylxanthone

Modify Date: 2024-01-11 18:37:59

1,3,5-Trihydroxy-4-prenylxanthone Structure
1,3,5-Trihydroxy-4-prenylxanthone structure
 Common Name 1,3,5-Trihydroxy-4-prenylxanthone
CAS Number 53377-61-0 Molecular Weight 312.317
Density 1.4±0.1 g/cm3 Boiling Point 550.7±49.0 °C at 760 mmHg
Molecular Formula C18H16O5 Melting Point N/A
MSDS N/A Flash Point 204.3±23.3 °C

 Use of 1,3,5-Trihydroxy-4-prenylxanthone


1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC50 value of 3.0 μM[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities[2].

 Names

Name 1,3,5-Trihydroxy-4-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
Synonym More Synonyms

 1,3,5-Trihydroxy-4-prenylxanthone Biological Activity

Description 1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC50 value of 3.0 μM[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities[2].
Related Catalog
Target

PDE5:3 μM (IC50)

iNOS

Na+/H+ Exchanger

In Vitro 1,3,5-Trihydroxy-4-prenylxanthone（10-30 μM；18 小时）通过消除 IKK 磷酸化、IκB 降解和 NF-κB 核转位抑制 LPS 诱导的 iNOS 表达。 1,3,5-Trihydroxy-4-prenylxanthone 通过干扰 IRAK-1 的翻译后修饰来抑制 LPS 诱导的 iNOS 表达，从而阻断 TAK1 介导的 IKK 和 MAPK 信号转导激活，从而下调 NF-κB 和 AP-1 的激活[2]。 Western Blot Analysis[2] Cell Line: RAW264.7 macrophages Concentration: 10 μM, 20 μM and 30 μM Incubation Time: 18 hours Result: Showed suppression of LPS-induced iNOS expression. Suppressed the nuclear level of c-Fos and c-Jun (major components of activator protein-1, AP-1) and the phosphorylated level of upstream signal molecules, such as JNK and ERK.
References

[1]. [1] M Kobayashi, et al. Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis. Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9.  

[2]. Wen-Fei Chiou, et al. 1,3,5-trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1. Biochem Pharmacol. 2011 Mar 15;81(6):752-60.  

[3]. Chalisa Sabphon, et al. Phosphodiesterase inhibitory activity of the flavonoids and xanthones from Anaxagorea luzonensis. Nat Prod Commun. 2015 Feb;10(2):301-3.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 550.7±49.0 °C at 760 mmHg
Molecular Formula C18H16O5
Molecular Weight 312.317
Flash Point 204.3±23.3 °C
Exact Mass 312.099762
PSA 90.90000
LogP 3.26
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.676

 Safety Information

Hazard Codes Xi
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

9H-Xanthen-9-one, 1,3,5-trihydroxy-4-(3-methyl-2-buten-1-yl)-
1,3,5-trihydroxy-4-(3-methylbut-2-enyl)xanthen-9-one
1,3,5-Trihydroxy-4-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
2,4,6-trihydroxynitrobenzene
nitrophlorogucinol
Nitrophloroglucinol
1-Nitrophloroglucinol
1,3,5-trihydroxy-4-(3-methylbut-2-enyl)-9H-xanthen-9-one
1,3,5-Trihydroxy-2-nitrobenzene
2-nitro-phloroglucinol
hitrophloroglucinol
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Chemsrc provides 1,3,5-Trihydroxy-4-prenylxanthone(CAS#:53377-61-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 1,3,5-Trihydroxy-4-prenylxanthone are included as well.>> amp version: 1,3,5-Trihydroxy-4-prenylxanthone

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