PIT-1
Modify Date: 2024-01-05 17:49:20
PIT-1 structure
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Common Name | PIT-1 | ||
|---|---|---|---|---|
| CAS Number | 53501-41-0 | Molecular Weight | 351.765 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H10ClN3O4S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of PIT-1PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1]. |
| Name | N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1]. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C14H10ClN3O4S |
| Molecular Weight | 351.765 |
| Exact Mass | 351.008057 |
| PSA | 139.27000 |
| LogP | 4.28 |
| Index of Refraction | 1.747 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| RIDADR | UN 3077 9 / PGIII |
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Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Proc. Natl. Acad. Sci. U. S. A. 107(46) , 20126-31, (2010) The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell metabolism, cell survival, and apoptosis. Phosphatidylinositol-3,4,5-trisphosphate (PIP3), the product of PI3K activity... |
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Inhibition of cell migration by PITENINs: the role of ARF6.
Oncogene 31(39) , 4317-32, (2012) We have reported previously the development of small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activ... |
| Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]- |
| N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide |
| PIT-1 |
| Impentamine dihydrobromide |
| N-[(3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide |