8-Azido-ATP

Modify Date: 2024-01-09 12:07:34

8-Azido-ATP Structure
8-Azido-ATP structure
Common Name 8-Azido-ATP
CAS Number 53696-59-6 Molecular Weight 570.17500
Density N/A Boiling Point N/A
Molecular Formula C10H14N8NaO13P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 8-Azido-ATP


8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase[1].

 Names

Name 8-azidoadenosine 5'-triphosphate, sodium salt
Synonym More Synonyms

 8-Azido-ATP Biological Activity

Description 8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase[1].
Related Catalog
In Vitro 8-Azido-ATP can be used to identify the viral RNA polymerase on the basis of the ability of the analog to inhibit transcription activity associated with rotavirus particles on exposure to UV light[1]. 8-Azido-ATP (azido-ATP) decreases viral transcription in a dose-dependent manner[1]. 8-Azido-ATP blocks Kir6.2ΔC26 currents rather less potently than ATP, half-maximal inhibition (Ki) occurring at 2.8 ± 0.4 mM (n = 6) compared with 172 ± 7 mM for ATP (n = 6). The Hill coefficients were 0.9 ± 0.2 for 8-azido-ATP and 1.3 ± 0.1 for ATP[2].
References

[1]. S Valenzuela, et al. Photoaffinity labeling of rotavirus VP1 with 8-azido-ATP: identification of the viral RNA polymerase. J Virol. 1991 Jul;65(7):3964-7.

[2]. K Tanabe, et al. Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP. J Biol Chem. 1999 Feb 12;274(7):3931-3.

 Chemical & Physical Properties

Molecular Formula C10H14N8NaO13P3
Molecular Weight 570.17500
Exact Mass 569.97900
PSA 336.11000

 Safety Information

Hazard Codes Xi

 Synonyms

Adenosine 5'-(tetrahydrogen triphosphate),8-azido
8-Azido-D-adenosine5'-triphosphatesodiumsalt
8-AZIDOADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT
8-N3-ATP SODIUM SALT
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