pterostilbene

Modify Date: 2024-01-02 13:45:59

pterostilbene Structure
pterostilbene structure
 Common Name pterostilbene
CAS Number 537-42-8 Molecular Weight 256.296
Density 1.2±0.1 g/cm3 Boiling Point 420.5±35.0 °C at 760 mmHg
Molecular Formula C16H16O3 Melting Point 89-92ºC
MSDS Chinese USA Flash Point 208.1±25.9 °C
Symbol GHS05 GHS09
GHS05, GHS09		 Signal Word Danger

 Use of pterostilbene


Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium[1]. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties[1][4]. Pterostilbene blocks ROS production[3], also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide[4].

 Names

Name pterostilbene
Synonym More Synonyms

 pterostilbene Biological Activity

Description Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium[1]. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties[1][4]. Pterostilbene blocks ROS production[3], also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide[4].
Related Catalog
In Vitro Pterostilbene (0, 5, 25, 50, 100, 200 and 400 µM) shows inhibitory activity against the growth of HeLa cells, with IC50s of 101.2 µM and 65.9 µM at 24 and 48 hrs, respectively. Ipterostilbene (0, 25, 100 and 200 µM) also induces the apoptosis HeLa cells[2]. Pterostilbene (0.05, 0.1, 0.15 and 0.2 mM) has high anti-oxidant activity against DPPH, ABTS, hydroxyl, superoxide, hydrogen peroxide in a dose-dependent manner. Pterostilbene decreases lipid peroxides and hydroperoxides, reduces protein carbonyl groups and restores protein sulphydryl groups in response to damage by TBHP and As-Fe2+. Pterostilbene also inhibits single strand breaks in pBR322[4].
In Vivo Pterostilbene (30 mg/kg daily, p.o. for 21 days) inhibits reactive oxygen species production in the animal model of inflammation[3].
References

[1]. McCormack D, et al. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482.

[2]. Hong Bin W, et al. Pterostilbene (3',5'-dimethoxy-resveratrol) exerts potent antitumor effects in HeLa human cervical cancer cells via disruption of mitochondrial membrane potential, apoptosis induction and targeting m-TOR/PI3K/Akt signalling pathway. J BUON. 2018 Sep-Oct;23(5):1384-1389.

[3]. Perecko T, et al. The effects of pterostilbene on neutrophil activity in experimental model of arthritis. Biomed Res Int. 2013;2013:106041.

[4]. Acharya JD, et al. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26;13:238.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 420.5±35.0 °C at 760 mmHg
Melting Point 89-92ºC
Molecular Formula C16H16O3
Molecular Weight 256.296
Flash Point 208.1±25.9 °C
Exact Mass 256.109955
PSA 38.69000
LogP 4.13
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.640
Storage condition 2-8°C
Water Solubility DMSO: >20mg/mL

 Safety Information

Symbol GHS05 GHS09
GHS05, GHS09
Signal Word Danger
Hazard Statements H318-H411
Precautionary Statements P273-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R41;R51/53
Safety Phrases S26-S39-S61
RIDADR UN 3077
Packaging Group Ⅲ
Hazard Class 9.0
HS Code 2909500000

 Synthetic Route

 Customs

HS Code 2909500000
Summary 2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles43

More Articles
Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377.

Free Radic. Biol. Med. 83 , 214-26, (2015)

High dietary fructose is an important causative factor in the development of metabolic syndrome-associated glomerular podocyte oxidative stress and injury. Here, we identified microRNA-377 (miR-377) a...

Anti-proliferative effect of pterostilbene on rat hepatoma cells in culture.

Cytotechnology 67 , 671-80, (2015)

Pterostilbene, a methoxylated analogue of resveratrol, is a natural compound primarily found in blueberries and several types of grapes. However, little is known about the effect of pterostilbene on t...

Involvement of the Nrf2 pathway in the regulation of pterostilbene-induced apoptosis in HeLa cells via ER stress.

J. Pharmacol. Sci. 126(3) , 216-29, (2014)

Among the various cancer cell lines, HeLa cells were found to be sensitive to pterostilbene (Pte), a compound that is enriched in small fruits such as grapes and berries. However, the mechanism involv...

 Synonyms

4-(3,5-Dimethoxystyryl)phenol
4-[(E)-2-(3,5-Diméthoxyphényl)éthènyl]phénol
Phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)-
3,5-Dimethoxy-4'-hydroxy-trans-stilbene
3',5'-Dimethoxy-4-stilbenol
4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol
4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]phenol
(E)-4-(3,5-Dimethoxystyryl)phenol
trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene
Pterostilbene
4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
Phenol, 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]-
Pterostilbene,Pterocarpus marsupium
(E)-pterostilbene
4-Stilbenol, 3',5'-dimethoxy-, (E)-
3,5-dimethoxy-4'-hydroxystilbene
4'-hydroxy-3,5-dimethoxystilbene
4'-Hydroxy-3,5-dimethoxy-trans-stilbene
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