Oxfendazole

Modify Date: 2024-01-01 17:39:28

Oxfendazole structure	Common Name	Oxfendazole
	CAS Number	53716-50-0	Molecular Weight	315.347
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₃N₃O₃S	Melting Point	253ºC
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Oxfendazole

Oxfendazole is the sulfoxide form of fenbendazole which is a broad spectrum benzimidazole anthelmintic. Target: AntiparasiticOxfendazole is the sulfoxide form of fenbendazole, a broad spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against roundworm, strongyles and pinworms.[1]. Pigs in the treated group received Oxfendazole orally at 30 mg/kg dose. At five days post-treatment, animals were sacrificed and the clinical efficacy of the Oxfendazole treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. Oxfendazole treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, Oxfendazole orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp [1].

Name	oxfendazole
Synonym	More Synonyms

Description	Oxfendazole is the sulfoxide form of fenbendazole which is a broad spectrum benzimidazole anthelmintic. Target: AntiparasiticOxfendazole is the sulfoxide form of fenbendazole, a broad spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against roundworm, strongyles and pinworms.[1]. Pigs in the treated group received Oxfendazole orally at 30 mg/kg dose. At five days post-treatment, animals were sacrificed and the clinical efficacy of the Oxfendazole treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. Oxfendazole treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, Oxfendazole orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp [1].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. http://www.chemicalland21.com/lifescience/phar/OXFENDAZOLE.htm [2]. Alvarez, L., et al., Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs. Veterinary parasitology, 2013. 194(1): p. 70-74.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

References

[1]. http://www.chemicalland21.com/lifescience/phar/OXFENDAZOLE.htm

[2]. Alvarez, L., et al., Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs. Veterinary parasitology, 2013. 194(1): p. 70-74.

Density	1.5±0.1 g/cm3
Melting Point	253ºC
Molecular Formula	C₁₅H₁₃N₃O₃S
Molecular Weight	315.347
Exact Mass	315.067749
PSA	103.29000
LogP	1.36
Index of Refraction	1.736
Storage condition	2-8°C

Oxfendazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD0808000

CHEMICAL NAME :: Carbamic acid, (5-(phenylsulfinyl)-1H-benzimidazol-2-yl)-, methyl ester

CAS REGISTRY NUMBER :: 53716-50-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H13-N3-O3-S

MOLECULAR WEIGHT :: 315.37

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 HSO&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 126 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 22500 ug/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 22500 ug/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - live birth index (measured after birth)

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 2 mg/L

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	FD0835000

fenbendazole

CAS#:43210-67-9

~99%

Oxfendazole

CAS#:53716-50-0

Literature: Hoechst Aktiengesellschaft Patent: US4792610 A1, 1988 ;

Precursor 1
CAS#:43210-67-9 fenbendazole
DownStream 0

Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

The effect of feed intake on the rate of flow of digesta and the disposition and activity of oxfendazole in sheep.

Int. J. Parasitol. 23(4) , 477-84, (1993)

Within 3 h of intra-ruminal (IR) administration oxfendazole (OFZ) was extensively associated with digesta particulate material. This association appeared to be a passive adsorption/desorption since sh...

Preparation, characterization and application of a new stir bar sorptive extraction based on poly(vinylphthalimide-co-N,N'-methylenebisacrylamide) monolith.

J. Sep. Sci. 34(23) , 3418-25, (2011)

In this study, a new stir bar sorptive extraction (SBSE) coating based on poly(vinylphthalimide-co-N,N'-methylenebisacrylamide) monolith (SBSE-VPMB) was prepared. The influences of the contents of mon...

systamex

Methyl [5-(Phenylsulfinyl)benzimidazol-2-yl]carbamate

MFCD00133728

UNII:OMP2H17F9E

CFDZ

LODITAC

synanthic

hoe8105

Carbamic acid, N-[5-(phenylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester

Oxfendazole

EINECS 258-714-5

Methyl 5-(phenylsulfinyl)-benzimidazol-2-carbamate

rs-8858

Methyl [5-(phenylsulfinyl)-1H-benzimidazol-2-yl]carbamate

repidose

ofdz

[5-(Phenylsulfinyl)benzimidazol-2-yl]carbamic Acid Methyl Ester

Fenbendazole Sulfoxide

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Oxfendazole

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Oxfendazole Biological Activity

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