NP-313
NP-313 structure
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Common Name | NP-313 | ||
|---|---|---|---|---|
| CAS Number | 5397-78-4 | Molecular Weight | 249.65000 | |
| Density | 1.44g/cm3 | Boiling Point | 427.7ºC at 760 mmHg | |
| Molecular Formula | C12H8ClNO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 212.5ºC | |
Use of NP-313NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1]. |
| Name | N-(3-chloro-1,4-dioxonaphthalen-2-yl)acetamide |
|---|---|
| Synonym | More Synonyms |
| Description | NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1]. |
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| Related Catalog | |
| In Vitro | NP-313 (0-80 μM)可以以剂量依赖的方式抑制血小板的聚集。其中，对凝血酶和 A23187 诱导的血小板聚集，NP-313 的最大抑制程度可分别达到约 80% 和 60%[1]。 NP-313 (0-8 μM) 浓度依赖性地抑制 P-选择素表达以及胶原蛋白或者是凝血酶诱导的人血小板中血栓素 B 2 (TXB2) 生成。同时，NP-313 抑制 COX-1 和 TXA 2合酶的 IC 50 值分别为 1.5 和 3.9 µM[1]。 |
| In Vivo | NP-313 (i.v., 4-16 µg/g)在雄性 ICR 小鼠中显着延长了闭塞时间 (TTO)，延长了出血时间，抑制了由胶原蛋白 (10 µg/mL) 引起的血小板聚集[1]。 |
| References |
| Density | 1.44g/cm3 |
|---|---|
| Boiling Point | 427.7ºC at 760 mmHg |
| Molecular Formula | C12H8ClNO3 |
| Molecular Weight | 249.65000 |
| Flash Point | 212.5ºC |
| Exact Mass | 249.01900 |
| PSA | 63.24000 |
| LogP | 2.04300 |
| Index of Refraction | 1.62 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2924299090 |
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~10%
NP-313 CAS#:5397-78-4 |
| Literature: Lien, Jin-Cherng; Wu, Chi-Rei; Hour, Mann-Jen; Huang, Li-Jiau; Huang, Tur-Fu; Kuo, Sheng-Chu Archiv der Pharmazie, 2008 , vol. 341, # 10 p. 639 - 644 |
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~81%
NP-313 CAS#:5397-78-4 |
| Literature: Egleton, James E.; Thinnes, Cyrille C.; Seden, Peter T.; Laurieri, Nicola; Lee, Siu Po; Hadavizadeh, Kate S.; Measures, Angelina R.; Jones, Alan M.; Thompson, Sam; Varney, Amy; Wynne, Graham M.; Ryan, Ali; Sim, Edith; Russell, Angela J. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 3030 - 3054 |
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~%
NP-313 CAS#:5397-78-4 |
| Literature: Diaz, Ramiro; Reyes, Oscar; Francois, Angelica; Leiva, Ana Maria; Loeb, Barbara Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6463 - 6467 |
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~%
NP-313 CAS#:5397-78-4 |
| Literature: Hammam,A.S.; Osman,A.-M. Journal fuer Praktische Chemie (Leipzig), 1977 , vol. 319, p. 254 - 258 |
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~%
NP-313 CAS#:5397-78-4 |
| Literature: Fries; Ochwat Chemische Berichte, 1923 , vol. 56, p. 1298 |
| Precursor 6 | |
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| DownStream 10 | |
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CAS#:58907-77-0| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| 2-Acetamido-3-chloro-1,4-naphthoquinone |
| 2-Chloro-3-acetamidonaphthoquinone |
| 2-N-acteylamino-3-chloro-1,4-naphthoquinone |
| 2-acetylamino-3-chloro-1,4-naphthoquinone |