3,4-Diaminopyridine

Modify Date: 2024-01-02 17:11:30

3,4-Diaminopyridine structure	Common Name	3,4-Diaminopyridine
	CAS Number	54-96-6	Molecular Weight	109.129
	Density	1.3±0.1 g/cm3	Boiling Point	369.3±22.0 °C at 760 mmHg
	Molecular Formula	C₅H₇N₃	Melting Point	216-218 °C(lit.)
	MSDS	Chinese USA	Flash Point	204.9±9.5 °C
	Symbol	GHS06	Signal Word	Danger

Use of 3,4-Diaminopyridine

Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases.Target: OthersAmifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is increased. Ca2+ channels can then be open for a longer time and allow greater acetylcholine release to stimulate muscle at the end plate. A 2005 systematic review from the Cochrane Collaboration found some data favouring its use in LEMS. Amifampridine is also used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. From Wikipedia.

Name	3,4-Diaminopyridine
Synonym	More Synonyms

Description	Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases.Target: OthersAmifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is increased. Ca2+ channels can then be open for a longer time and allow greater acetylcholine release to stimulate muscle at the end plate. A 2005 systematic review from the Cochrane Collaboration found some data favouring its use in LEMS. Amifampridine is also used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. From Wikipedia.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. http://en.wikipedia.org/wiki/3,4-Diaminopyridine#cite_note-4

Density	1.3±0.1 g/cm3
Boiling Point	369.3±22.0 °C at 760 mmHg
Melting Point	216-218 °C(lit.)
Molecular Formula	C₅H₇N₃
Molecular Weight	109.129
Flash Point	204.9±9.5 °C
Exact Mass	109.063995
PSA	64.93000
LogP	-0.09
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.676
Water Solubility	24 g/L (20 ºC)

3,4-Diaminopyridine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7600000

CHEMICAL NAME :: Pyridine, 3,4-diamino-

CAS REGISTRY NUMBER :: 54-96-6

BEILSTEIN REFERENCE NO. :: 0110232

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H7-N3

MOLECULAR WEIGHT :: 109.15

WISWESSER LINE NOTATION :: T6NJ CZ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,296,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 150,413,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H330-H311-H315-H319-H335
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R36/37/38
Safety Phrases	S26-S28-S36/37/39-S45-S37/39-S28A
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	US7600000
Packaging Group	I
Hazard Class	6.1
HS Code	29333999

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Precursor 9
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CAS#:94602-04-7 4-Ethoxy-3-nitr... CAS#:5435-54-1 3-Nitro-4-pyridinol CAS#:504-24-5 4-AMINOPYRIDINE CAS#:5221-42-1 N-(PYRIDIN-4-YL...
CAS#:79371-42-9 4-acetamido-3-n...
DownStream 10
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CAS#:272-97-9 3H-Imidazo[4,5-... CAS#:75115-28-5 N3-Benzyl-3,4-p...

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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3-Pyridinamine, 1,4-dihydro-4-imino-

3,4-Pyridinedramine

3,4-DIAMINOPYRIDINE FOR SYNTHESIS

3,4-Diaminopyridin

3,4-DAP

3,4-diamino-pyridine

3,4-diamino-pyridin

3,4-Diaminopyridine

Amifampridine

3 4-DIAMINOPYRIDINE

Pyridine-3,4-diamine

pyridin-3,4-diaMine

4,5-diaminopyridine

3,4DIAMINOPYRIDINE

EINECS 200-220-9

3,4 DI AMINO PYRIDINE

Pyridin-3,4-diamin

3-amino-4-pyridinylamine

MFCD00006401

3,4-Pyridinediamine

diamino-3,4pyridine

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China
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China
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China
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China
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China
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3,4-Diaminopyridine

Use of 3,4-Diaminopyridine

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