4-Methylaniline hydrochloride

Modify Date: 2024-01-02 17:43:32

4-Methylaniline hydrochloride structure	Common Name	4-Methylaniline hydrochloride
	CAS Number	540-23-8	Molecular Weight	143.61400
	Density	N/A	Boiling Point	200.4ºC
	Molecular Formula	C₇H₁₀ClN	Melting Point	243-245 °C(lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS06, GHS08, GHS09	Signal Word	Danger

Name	p-Toluidine hydrochloride
Synonym	More Synonyms

Boiling Point	200.4ºC
Melting Point	243-245 °C(lit.)
Molecular Formula	C₇H₁₀ClN
Molecular Weight	143.61400
Exact Mass	143.05000
PSA	26.02000
LogP	2.96040

4-Methylaniline hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU7525000

CHEMICAL NAME :: p-Toluidine, hydrochloride

CAS REGISTRY NUMBER :: 540-23-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C7-H9-N.Cl-H

MOLECULAR WEIGHT :: 143.63

WISWESSER LINE NOTATION :: ZR D1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 167,223,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 399 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 86 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83316 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 85 (estimated)

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H301-H311-H317-H319-H331-H351-H400
Precautionary Statements	P261-P273-P280-P301 + P310-P305 + P351 + P338-P311
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;N: Dangerous for the environment;
Risk Phrases	R23/24/25;R36;R40;R43;R50
Safety Phrases	S28-S36/37-S45-S61
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	XU7525000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2921430090

Precursor 9
CAS#:113827-45-5 As,As-diphenyl-... CAS#:106-49-0 p-Toluidine CAS#:99-99-0 4-Nitrotoluene CAS#:504405-07-6 4,4,5,5-tetrame...
CAS#:103-89-9 4'-Methylacetanilide CAS#:16634-82-5 2-Chloro-N-(4-m... CAS#:2739-12-0 N-methylaniline... CAS#:74234-58-5 3-methoxy-N-(p-...
CAS#:106-38-7 4-Bromotoluene
DownStream 10
CAS#:36711-56-5 4-(4-AMINO-BENZ... CAS#:321-64-2 Tacrine CAS#:608-05-9 5-Methylindolin... CAS#:15190-06-4 Benzeneacetonit...
CAS#:60-29-7 Diethyl ether CAS#:39593-08-3 1-(4-Methylphen... CAS#:19717-14-7 4-[(4-nitrobenz... CAS#:527-60-6 2,4,6-Trimethyl...
CAS#:3469-20-3 2,3-DIPHENYLINDOLE CAS#:36804-50-9 1H-Indole,5-met...

HS Code	2921430090
Summary	HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Exposure of hairdressers to ortho- and meta-toluidine in hair dyes.

Occup. Environ. Med. 72(1) , 57-63, (2015)

Carcinogenic aromatic amines derived from hair dyes have recently received new attention. One of these is ortho (o)-toluidine, which is classified as carcinogenic to humans.To clarify exposure of hair...

Two-dimensional fluorometry coupled with artificial neural networks: a novel method for on-line monitoring of complex biological processes.

Biotechnol. Bioeng. 72(3) , 297-306, (2001)

The use of two-dimensional scanning fluorometry as an on-line, noninvasive, in situ bioreactor monitoring technique is extended to complex bioprocesses using mixed cultures, with particular attention ...

First representative of optically active P-L-menthyl-substituted (aminomethyl)phosphine and its borane and metal complexes.

Inorg. Chem. 49(12) , 5407-12, (2010)

The first representative of 1,5-diaza-3,7-diphosphacyclooctanes (1) with chiral L-menthyl substituents on the phosphorus atoms was obtained by condensation of L-menthylphosphine with formaldehyde and ...

4-Methylaniline hydrochloride

EINECS 208-740-8

MFCD00035497

4-methylaniline,hydrochloride

p-Toluidine Hydrochloride