Isovaleramide

Modify Date: 2024-01-08 17:18:53

Isovaleramide Structure
Isovaleramide structure
Common Name Isovaleramide
CAS Number 541-46-8 Molecular Weight 101.14700
Density 0.901g/cm3 Boiling Point 232°C
Molecular Formula C5H11NO Melting Point 135 °C
MSDS N/A Flash Point 232°C

 Use of Isovaleramide


Isovaleramide is an active principle on central nervous system from Valeriana pavonii, as an anticonvulsant.Target:in vitro: Isovaleramide (300 μM) exhibits a 42% of inhibition of the binding of 3H-FNZ to its sites.in vivo: Isovaleramide at 100 mg/Kg, p.o, evidences a 90% index protection against the maximal electroshock seizure in mice (MES).

 Names

Name 3-methylbutanamide
Synonym More Synonyms

 Isovaleramide Biological Activity

Description Isovaleramide is an active principle on central nervous system from Valeriana pavonii, as an anticonvulsant.Target:in vitro: Isovaleramide (300 μM) exhibits a 42% of inhibition of the binding of 3H-FNZ to its sites.in vivo: Isovaleramide at 100 mg/Kg, p.o, evidences a 90% index protection against the maximal electroshock seizure in mice (MES).
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 Chemical & Physical Properties

Density 0.901g/cm3
Boiling Point 232°C
Melting Point 135 °C
Molecular Formula C5H11NO
Molecular Weight 101.14700
Flash Point 232°C
Exact Mass 101.08400
PSA 43.09000
LogP 1.21810
Index of Refraction 1.425
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EJ3650000
CHEMICAL NAME :
Butanamide, 3-methyl-
CAS REGISTRY NUMBER :
541-46-8
BEILSTEIN REFERENCE NO. :
1740789
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C5-H11-N-O
MOLECULAR WEIGHT :
101.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 10,453,1975

 Safety Information

Hazard Codes Xi
Safety Phrases S22-S24/25
RTECS EJ3650000
HS Code 2924199090

 Synthetic Route

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Isopentanamide
3-Methylbutyramide
Butanamide,3-methyl
dimethyl propionic acid amide
3-methylbutaneamide
MFCD00014807
Isovaleric acid amide
dimethyl propionamide
Isovaleramide
3-Methylbutanamide
3-methylbutylamide
EINECS 208-781-1
NPS 1776
Isovaleric amide
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