Cimetidine sulfoxide
Modify Date: 2024-01-13 11:41:59
Cimetidine sulfoxide structure
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Common Name | Cimetidine sulfoxide | ||
|---|---|---|---|---|
| CAS Number | 54237-72-8 | Molecular Weight | 341.260 | |
| Density | 1.39g/cm3 | Boiling Point | 608.6ºC at 760mmHg | |
| Molecular Formula | C10H16N6OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 321.8ºC | |
Use of Cimetidine sulfoxideCimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment[1]. |
| Name | cimetidine S-oxide |
|---|---|
| Synonym | More Synonyms |
| Description | Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment[1]. |
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| Related Catalog | |
| Target |
Histamine H2-receptor[1] |
| In Vitro | Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations (40 and 200 μM), but is masked by passive transfer at higher concentrations (400 μM). Cimetidine sulfoxide is detected after some incubations[2]. |
| In Vivo | The enantiomeric composition of Cimetidine sulfoxide is also determined in rat urine (24 h) following the administration of Cimetidine (30 mg/kg; po) to male Wistar rats. The enantiomeric ratio in this case is found to be (+/−) 57:43[3]. |
| References |
| Density | 1.39g/cm3 |
|---|---|
| Boiling Point | 608.6ºC at 760mmHg |
| Molecular Formula | C10H16N6OS |
| Molecular Weight | 341.260 |
| Flash Point | 321.8ºC |
| Exact Mass | 340.063995 |
| PSA | 125.17000 |
| LogP | 2.86438 |
| Index of Refraction | 1.665 |
| Hazard Codes | Xi |
|---|
| Guanidine, N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfinyl]ethyl]-, hydrochloride (1:2) |
| 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfinyl]ethyl]guanidine |
| Cimetidine sulfoxide |
| 1-Cyano-3-methyl-2-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfinyl}ethyl)guanidine dihydrochloride |