Umbellulone
Modify Date: 2024-01-03 09:09:08
Umbellulone structure
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Common Name | Umbellulone | ||
|---|---|---|---|---|
| CAS Number | 546-78-1 | Molecular Weight | 150.21800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H14O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of UmbelluloneUmbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1]. |
| Name | umbellulone |
|---|---|
| Synonym | More Synonyms |
| Description | Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1]. |
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| Related Catalog | |
| Target |
TRPA1 channel[1] |
| In Vitro | Umbellulone, from µM to sub-mM concentrations, selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells[1]. |
| In Vivo | Umbellulone (50–250 nM/5ul) causes an acute nocioceptive response in a dose-dependent manner in Trpa1+/+ mice[1]. Umbellulone (150 µg/kg; intravenous or intranasal) do not affect systemic blood pressure[1]. Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner[1]. Animal Model: Sprague-Dawley rats (male, 250 g)[1] Dosage: 30 μg/kg, 75 μg/kg, 150 μg/kg Administration: Intravenously Result: Increased meningeal blood flow in a dose-dependent manner. |
| References |
| Molecular Formula | C10H14O |
|---|---|
| Molecular Weight | 150.21800 |
| Exact Mass | 150.10400 |
| PSA | 17.07000 |
| LogP | 2.17770 |
| Storage condition | -20°C |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:89-83-8
CAS#:490-06-2|
Hemisynthesis of dihydroumbellulols from umbellulone: new cooling compounds.
J. Agric. Food Chem. 59(2) , 677-83, (2011) Although menthol is a common ingredient used in food products, other molecules also evoke coolness through stimulation of the somatosensory system. To discover new molecules having cooling properties,... |
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Herbalism helps headache.
Brain 135(Pt 2) , 318-9, (2012)
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| Thuj-3-en-2-on |