4-(4-Hydroxyphenyl)-2-butanone

Modify Date: 2024-01-02 01:12:33

4-(4-Hydroxyphenyl)-2-butanone structure	Common Name	4-(4-Hydroxyphenyl)-2-butanone
	CAS Number	5471-51-2	Molecular Weight	164.201
	Density	1.1±0.1 g/cm3	Boiling Point	292.2±15.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂O₂	Melting Point	81-85 °C(lit.)
	MSDS	Chinese USA	Flash Point	122.9±13.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-(4-Hydroxyphenyl)-2-butanone

Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.

Name	raspberry ketone
Synonym	More Synonyms

Description	Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Phenols Research Areas >> Cardiovascular Disease
Target	PPAR-α
In Vitro	Raspberry ketone (1, 10, 20, and 50 μM) suppresses adipogenesis and lipid accumulation in 3T3-L1 pre-adipocytes. Raspberry ketone (10 µM) significantly blocks C/EBPα, PPARγ, and aP2 expression and increases the expression of ATGL and HSL, and CPT1B[1].
In Vivo	Raspberry ketone (0.5%, 1%, or 2%) increasses the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol contents (LDL-C), ISI (insulin-sensitivr index), PPAR-α and LDLR, decreases the serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), IRI (insulin resistance index), GLU (glucose), INS (insulin-sensitivr index), LEP (leptin), and TNF-α in rats compared with a high-fat diet-induced NASH model. Raspberry ketone also causes increased SOD activities[2]. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity[3].
Cell Assay	For the cytotoxicity study, 3T3-L1 pre-adipocytes are cultured and differentiated. After Raspberry ketone treatment for 4 d in DMEM containing 10% fetal bovine serum, the lactate dehydrogenase (LDH) concentration in the medium is immediately detected with the CytoTox 96 nonradioactive cytotoxicity assay kit[1].
Animal Admin	During the experimental period, the animal room holds four rats per cage, with free access to water and food, under conditions of temperature controlled at 20-26°C, humidity at 40-70%, and a 12/12-h day-night light cycle. Rats are fed with normal diet for 1 week and then randomly divided into five groups: normal control (NC) group (n=8) fed normal diet for 8 weeks, the model control (MC) group (n=8) fed high-fat diet (82% standard diet, 8.3% yolk powder, 9.0% lard, 0.5% cholesterol, and 0.2% sodium taurocholate), the Raspberry ketone low-dose (RKL) group (n=8), the Raspberry ketone middle-dose (RKM) group (n=8), and the Raspberry ketone high-dose (RKH) group (n=8). Rats are first fed with high-fat diet for 4 weeks, and then these rats are given intragastrically 0.5%, 1%, or 2% Raspberry ketone. The first two groups of rats are intragastrically administered salad oil at the same dose (2 mL/day per rat) once a day at 10:00 a.m., lasting for 4 weeks[2].
References	[1]. Park KS. Raspberry ketone, a naturally occurring phenolic compound, inhibits adipogenic and lipogenic gene expression in 3T3-L1 adipocytes. Pharm Biol. 2015 Jun;53(6):870-5. [2]. Wang L, et al. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food. 2012 May;15(5):495-503. [3]. Khan V, et al. Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats. Life Sci. 2018 Feb 1;194:205-212.

Density	1.1±0.1 g/cm3
Boiling Point	292.2±15.0 °C at 760 mmHg
Melting Point	81-85 °C(lit.)
Molecular Formula	C₁₀H₁₂O₂
Molecular Weight	164.201
Flash Point	122.9±13.0 °C
Exact Mass	164.083725
PSA	37.30000
LogP	0.94
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.535
Storage condition	Refrigerator

4-(4-Hydroxyphenyl)-2-butanone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL8925000

CHEMICAL NAME :: 2-Butanone, 4-(p-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 5471-51-2

BEILSTEIN REFERENCE NO. :: 0776080

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H12-O2

MOLECULAR WEIGHT :: 164.22

WISWESSER LINE NOTATION :: QR D2V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - analgesia

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,349,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - analgesia

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,349,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4912 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 13 No. of Employees: 3245 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4912 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	EL8925000
HS Code	2914501100

Precursor 10
CAS#:1445875-25-1 4-(4-((triisopr... CAS#:78-94-4 Methyl vinyl ketone CAS#:108-95-2 Phenol CAS#:22214-30-8 (E)-4-(4-Hydrox...
CAS#:59092-94-3 (+)-Rhododendrol CAS#:123-08-0 4-hydroxybenzal... CAS#:67-64-1 Acetone CAS#:590-90-9 4-Hydroxy-2-butanone
CAS#:598-32-3 3-Buten-2-ol CAS#:540-38-5 4-Iodophenol
DownStream 9
CAS#:101268-32-0 2-[4-(3-hydroxy... CAS#:104-20-1 p-Methoxybenzyl... CAS#:38963-94-9 Raspberryketone... CAS#:3572-06-3 Cuelure
CAS#:1638-22-8 4-Butylphenol CAS#:94135-08-7 4-(3-oxobutyl)p... CAS#:4237-73-4 Benzenepropanol... CAS#:5440-26-6 2,3-Butanedione...
CAS#:522617-84-1 4-(4-trimethyls...

HS Code	2914501100
Summary	HS: 2914501100. 4-(4-hydroxyphenyl)butan-2-one. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tarrif:5.5%. general tariff:30.0%

A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols.

J. Dermatol. Sci. 80 , 18-24, (2015)

Tyrosinase is able to oxidize a great number of phenols and catechols to form ortho-quinones. Ortho-quinones are highly reactive compounds that exert cytotoxicity through binding with thiol enzymes an...

Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay.

Bioorg. Med. Chem. Lett. 20 , 2111-4, (2010)

The effect of essential oils, such as raspberry ketone, on androgen (AR) receptor was investigated using a MDA-kb2 human breast cancer cell line for predicting potential AR activity. Among them, eugen...

Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts.

Anal. Bioanal. Chem 407(3) , 803-12, (2015)

This paper describes the synthesis of novel molecularly imprinted polymers (MIPs), prepared by a noncovalent imprinting approach, for cleanup and preconcentration of curcumin (CUR) and bisdemethoxycur...

Oxyphenalon

4-hydroxy benzyl acetone

Raspberry keton

4-(4-Hydroxyphenyl)-2-butanone

Frambinone

Rheosmin

OXYPHENONE

OXYPHENYLON

Raspberry ketone

EINECS 226-806-4

RASBERRY KETONE

MFCD00002394

p-Hydroxy benzylacetone

FEMA 2588

OXANONE

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-(4-Hydroxyphenyl)-2-butanone
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: 4-(4-Hydroxyphenyl)-2-butanone
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-(4-Hydroxyphenyl)-2-butanone
Price: ￥138.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: 4-(4-Hydroxyphenyl)-2-butanone
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Raspberry ketone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Raspberry Ketone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: Raspberry Ketone
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

Get all suppliers and price by the below link:

4-(4-Hydroxyphenyl)-2-butanone suppliers

Price: ￥43/25g

Reference only. check more 4-(4-Hydroxyphenyl)-2-butanone price

4-(4-Hydroxyphenyl)-2-butanone

Use of 4-(4-Hydroxyphenyl)-2-butanone

Names