genkwadaphnin

Modify Date: 2024-01-05 14:26:57

genkwadaphnin Structure
genkwadaphnin structure
Common Name genkwadaphnin
CAS Number 55073-32-0 Molecular Weight 602.62800
Density N/A Boiling Point N/A
Molecular Formula C34H34O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of genkwadaphnin


Genkwadaphnin is a daphnane diterpenoid, targeting of importin-β1 to reduce the nuclear accumulation of key CRPC drivers, and shut down their downstream oncogenic signaling. Genkwadaphnin shows potent anti-tumor activity and inhibits castration-resistant prostate cancer (CRPC) in vivo in mice[1].

 Names

Name genkwadaphnin
Synonym More Synonyms

 genkwadaphnin Biological Activity

Description Genkwadaphnin is a daphnane diterpenoid, targeting of importin-β1 to reduce the nuclear accumulation of key CRPC drivers, and shut down their downstream oncogenic signaling. Genkwadaphnin shows potent anti-tumor activity and inhibits castration-resistant prostate cancer (CRPC) in vivo in mice[1].
Related Catalog
Target

Importin-β1[1]

References

[1]. Huang JL, et al. Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer. J Am Chem Soc. 2022 Sep 14.

 Chemical & Physical Properties

Molecular Formula C34H34O10
Molecular Weight 602.62800
Exact Mass 602.21500
PSA 144.28000
LogP 2.16840

 Precursor & DownStream

Precursor  0

DownStream  2

 Synonyms

Benzoat v. 12-Hydroxydaphnetoxin
genkwadaphin
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