Salsalate

Modify Date: 2024-01-08 15:20:41

Salsalate Structure
Salsalate structure
 Common Name Salsalate
CAS Number 552-94-3 Molecular Weight 258.226
Density 1.4±0.1 g/cm3 Boiling Point 482.9±25.0 °C at 760 mmHg
Molecular Formula C14H10O5 Melting Point 139-151 °C
MSDS Chinese USA Flash Point 188.0±16.7 °C
Symbol GHS07 GHS09
GHS07, GHS09		 Signal Word Warning

 Use of Salsalate


Salsalate is a nonsteroidal anti-inflammatory drug (NSAID).Target：Salsalate is a medication that belongs to the salicylate and non-steroidal anti-inflammatory drug (NSAID) classes. Relative to other NSAIDs, Salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several pro inflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein. Common conditions in which Salsalate may be indicated include inflammatory disorders such as rheumatoid arthritis or noninflammatory disorders such as osteoarthritis.

 Names

Name salsalate
Synonym More Synonyms

 Salsalate Biological Activity

Description Salsalate is a nonsteroidal anti-inflammatory drug (NSAID).Target：Salsalate is a medication that belongs to the salicylate and non-steroidal anti-inflammatory drug (NSAID) classes. Relative to other NSAIDs, Salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several pro inflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein. Common conditions in which Salsalate may be indicated include inflammatory disorders such as rheumatoid arthritis or noninflammatory disorders such as osteoarthritis.
Related Catalog

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 482.9±25.0 °C at 760 mmHg
Melting Point 139-151 °C
Molecular Formula C14H10O5
Molecular Weight 258.226
Flash Point 188.0±16.7 °C
Exact Mass 258.052826
PSA 83.83000
LogP 3.05
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.646
Storage condition room temp

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DH2080000
CHEMICAL NAME :
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
CAS REGISTRY NUMBER :
552-94-3
BEILSTEIN REFERENCE NO. :
2590908
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C14-H10-O5
MOLECULAR WEIGHT :
258.24
WISWESSER LINE NOTATION :
QVR BOVR BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
2229 mg/kg/2Y-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 107,116,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1020 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1101,1980
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
665 mg/kg
SEX/DURATION :
female 17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 29,250,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80509 No. of Facilities: 105 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3179 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80509 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 629 (estimated) No. of Female Employees: 291 (estimated)

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H400
Precautionary Statements P301 + P312 + P330
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases 37/39-26
RIDADR 3077.0
RTECS DH2080000
HS Code 2918230000

 Synthetic Route

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles28

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Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes.

Br. J. Pharmacol. 172 , 5293-305, (2016)

Salsalate (salicylsalicylic acid) is an anti-inflammatory drug that was recently found to exert beneficial metabolic effects on glucose and lipid metabolism. Although its utility in the prevention and...

Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.

J. Pharmacol. Exp. Ther. 339(3) , 896-904, (2011)

Type 2 diabetes mellitus (T2DM) arises owing to insulin resistance and β-cell dysfunction. Chronic inflammation is widely identified as a cause of T2DM. The Goto-Kakizaki (GK) rat is a spontaneous rod...

 Synonyms

Disalcid
EINECS 209-027-4
2-[(2-Hydroxybenzoyl)oxy]benzoic acid
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
2-(2-hydroxybenzoyl)oxybenzoic acid
2-salicyloyloxy-benzoic acid
Salicylsalicylic acid
Saloxium
Diacesal
Salicylic Acid Bimolecular Ester
Disalicylic acid
Salicyl salicylate
2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid
Diplosal
Salina
Salicylic Acid Salicylate
carboxyphenyl salicylate
Disalyl
MFCD00020252
Salsalate
sasapyrine
Sasapyrinum
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