Litorin

Modify Date: 2024-01-08 20:35:10

Litorin Structure
Litorin structure
 Common Name Litorin
CAS Number 55749-97-8 Molecular Weight 1085.24
Density 1.34 g/cm3 Boiling Point 1693.3ºC at 760 mmHg
Molecular Formula C51H68N14O11S Melting Point N/A
MSDS Chinese Flash Point 977.9ºC

 Use of Litorin


Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].

 Names

Name Litorin
Synonym More Synonyms

 Litorin Biological Activity

Description Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].
Related Catalog
In Vitro 99mTc-Litorin is developed for non-invasive imaging of tumors with overexpressed gastrin-releasing peptide receptors (GRP-R)[1]. [D-Phe1,Leu8,9]Litorin inhibits binding of 125I-[Tyr4] BN to murine Swiss 3T3 cells with a Ki of 5.1 nM[2]. Litorin stimulates 3H-Thymidine incorporation in murine Swiss 3T3 cells with an EC50 of 2.3 nM[2].
In Vivo Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in in vivo experiments[2].
References

[1]. Kam Leung. 99mTc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2. Molecular Imaging and Contrast Agent Database (MICAD). 2007 Oct 1.

[2]. J M Siegfried, et al. Effects of bombesin and gastrin-releasing peptide on human bronchial epithelial cells from a series of donors: individual variation and modulation by bombesin analogs. Anat Rec. 1993 May;236(1):241-7.

 Chemical & Physical Properties

Density 1.34 g/cm3
Boiling Point 1693.3ºC at 760 mmHg
Molecular Formula C51H68N14O11S
Molecular Weight 1085.24
Flash Point 977.9ºC
Exact Mass 1084.49000
PSA 417.85000
LogP 2.74370
Index of Refraction 1.615

 Synonyms

5-Oxo-L-Pro-L-Gln-L-Trp-L-Ala-L-Val-Gly-L-His-L-Phe-L-Met-NH2
Efonidipine hydrochloride monoethanolate
M.W. 1084.47 C51H68N14O11S
pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
2-De-L-Val-3-de-L-Pro-ranatensin
Pituitary adenylate cyclase activating fragment 21-38
pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2,Pituitary adenylate cyclase activating fragment 21-38
GLP-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
PYR-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
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