Ethyl [(4-methylphenyl)sulfonyl]carbamate

Modify Date: 2024-01-02 12:06:37

Ethyl [(4-methylphenyl)sulfonyl]carbamate Structure
Ethyl [(4-methylphenyl)sulfonyl]carbamate structure
Common Name Ethyl [(4-methylphenyl)sulfonyl]carbamate
CAS Number 5577-13-9 Molecular Weight 243.279
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C10H13NO4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ethyl [(4-methylphenyl)sulfonyl]carbamate


Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

 Names

Name Ethyl N-(4-methylphenyl)sulfonylcarbamate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C10H13NO4S
Molecular Weight 243.279
Exact Mass 243.056534
PSA 80.85000
LogP 1.86
Index of Refraction 1.530

 Safety Information

Hazard Codes Xi
HS Code 2935009090

 Synthetic Route

~88%

Ethyl [(4-methylphenyl)sulfonyl]carbamate Structure

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Xi, Pin-xian; Xu, Zhi-hong; Liu, Xiao-hui; Cheng, Feng-juan; Zeng, Zheng-zhi Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 71, # 2 p. 523 - 528 Title/Abstract Full Text View citing articles Show Details Xi, Pin-Xian; Xu, Zhi-Hong; Liu, Xiao-Hui; Chen, Feng-Juan; Huang, Liang; Zeng, Zheng-Zhi Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 541 - 546

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Ethyl [(4-methylphenyl)sulfonyl]carbamate Structure

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: US5326796 A1, ;

~91%

Ethyl [(4-methylphenyl)sulfonyl]carbamate Structure

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Guo, Xiaoguang; Shang, Jianpeng; Li, Jian; Wang, Liguo; Ma, Yubo; Shi, Feng; Deng, Youquan Synthetic Communications, 2011 , vol. 41, # 8 p. 1102 - 1111

~33%

Ethyl [(4-methylphenyl)sulfonyl]carbamate Structure

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Bittner, Shmuel; Assaf, Yonit; Krief, Penina; Pomerantz, Martin; Ziemnicka, Barbara T.; Smith, Christina G. Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1712 - 1718

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Ethyl [(4-methylphenyl)sulfonyl]carbamate Structure

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

~%

Ethyl [(4-methylphenyl)sulfonyl]carbamate Structure

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

Tosylcarbamic acid ethyl ester
Ethyl [(4-methylphenyl)sulfonyl]carbamate
ethyl N-(4-toluenesulfonyl)carbamate
ethyl tosylcarbaMate
Ethyl [(4-methylphenyl)sulphonyl]carbamate
Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester
Tosylurethane
ethoxycarbonamide of p-toluenebenzenesulfoacid
ethyl p-tosylcarbamate
(toluene-4-sulfonyl)-carbamic acid ethyl ester
ethyl N-(tosyl)carbamate
Carbamic acid, [(4-methylphenyl)sulfonyl]-, ethyl ester
N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester
2OVMSWR D1
N-(p-Tolylsulfonyl)carbamic acid ethyl ester
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