Triamcinolone hexacetonide

Modify Date: 2024-01-06 23:39:23

Triamcinolone hexacetonide Structure
Triamcinolone hexacetonide structure
Common Name Triamcinolone hexacetonide
CAS Number 5611-51-8 Molecular Weight 532.64100
Density 1.24 g/cm3 Boiling Point 619.5ºC
Molecular Formula C30H41FO7 Melting Point N/A
MSDS N/A Flash Point 328.5ºC

 Use of Triamcinolone hexacetonide


Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases.

 Names

Name triamcinolone hexacetonide
Synonym More Synonyms

 Triamcinolone hexacetonide Biological Activity

Description Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases.
Related Catalog
In Vivo Triamcinolone hexacetonide produces a marked, dose-dependent protective effect in the model of chemically induced articular cartilage damage. Guinea pig injected with Triamcinolone hexacetonide shows much less prominent fibrillation and osteophytes. Cell loss is less extensive. A single injection of Triamcinolone hexacetonide into the ipsilateral knee of rabbits which have been subjected to partial lateral meniscectomy and transection of the sesamoid and collateral fibular ligaments reduces chondrocyte cloning, loss of cells, osteophyte formation, and fibrillation[1]. The half-life of commercially available Triamcinolone hexacetonide in the vitreous is double that of Triamcinolone hexacetonide, but the former is toxic to the retina in this rabbit model. Reformulated iso-osmolar Triamcinolone hexacetonide shows no evidence of deleterious effects to retina function or structure[2]. Local application of Triamcinolone hexacetonide at a site of lingual nerve injury leads to changes that are potentially beneficial such as reduced mechanical sensitivity and enhanced regeneration[3].
Animal Admin Guinea pigs: Animals are given intraarticular injection of 0.1 mL of Triamcinolone hexacetonide provided a dose of 0.40 mg/kg (groups 2 and 3) or 0.04 mg/kg (groups 4 and 5). The volume of CMC injected into the knees of group 6 animals is the same as that used for the intraarticular injections in the other groups, i.e., 0.1 mL. When the animals are killed, both knees are immediately opened and examined grossly[1].
References

[1]. Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74.

[2]. Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr;24(2):197-205.

[3]. Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9.

 Chemical & Physical Properties

Density 1.24 g/cm3
Boiling Point 619.5ºC
Molecular Formula C30H41FO7
Molecular Weight 532.64100
Flash Point 328.5ºC
Exact Mass 532.28400
PSA 99.13000
LogP 4.40590
Index of Refraction 1.556

 MSDS


Section 1. Chemical Product and Company Identification
Triamcinolone Hexacetonide
Common Name/
Trade Name
Triamcinolone Hexacetonide

Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention if irritation occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious InhalationNot available.
IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious IngestionNot available.

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash PointsNot available.
Flammable LimitsNot available.
Products of CombustionThese products are carbon oxides (CO, CO2), halogenated compounds.
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various SubstancesNon-flammable in presence of shocks.
Explosion Hazards in Presence Slightly explosive in presence of open flames and sparks.
Non-explosive in presence of shocks.
of Various Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet.
As with most organic solids, fire is possible at elevated temperatures
Special Remarks on
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
Hazardsexplosion hazard.

Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Triamcinolone Hexacetonide

Section 7. Handling and Storage
PrecautionsKeep away from heat. Keep away from sources of ignition. Do not breathe dust.
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Crystalline powder.)OdorOdorless.
TasteNot available.
Molecular Weight532.64 g/mole
White. Off-white.
Color
Not available.
pH (1% soln/water)
Boiling PointNot available.
Decomposition temperature: 295°C (563°F)
Melting Point
Critical TemperatureNot available.
Specific GravityNot available.
Vapor PressureNot applicable.
Vapor DensityNot available.
VolatilityNot available.
Odor ThresholdNot available.
Not available.
Water/Oil Dist. Coeff.
Ionicity (in Water)Not available.
Dispersion PropertiesNot available.
SolubilityInsoluble in cold water, hot water.

Section 10. Stability and Reactivity Data
StabilityThe product is stable.
Not available.
Instability Temperature
Conditions of InstabilityNot available.
Incompatibility with variousNot available.
substances
CorrosivityNot available.
Triamcinolone Hexacetonide
Not available.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
PolymerizationWill not occur.

Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsLD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onMay cause adverse reproductive effects and birth defects (teratogenic) Human: passes through the placenta.
Chronic Effects on Humans
Special Remarks on otherPotential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritaition.
Ingestion: May cause gastrointestinal tract irritation with abdominal distension, nausea, vomiting. May cause
ulcerative esophagitis and peptic ulcers. May cause fluid and electrolyte disturbances resulting in sodium
retention, fluid retention, congestive heart failure in susceptible individuals, potassium loss, hypokalemic alkalosis,
increased calcium excretion, mild diuresis, polyuria, polydypsia, hypertension. May cause depression of
appetite/anorexia in contrast to voracious appetite ordinarily encountered with other glucocorticoids. Common
corticosteroids may cause euphoria whereas Triamcinolone may cause mood depression.
May cause steroid myopathy/muscular atrophy with loss of muscle mass and muscle weakness involving
muscles of the thighs, pelvis, and low back, muscle cramps. May cause other musculoskeletal effects such as
Osteoporosis, vertebral conpression fractures, pathologic fractures of long bones. May affect immune
system/immune response and increase the susceptibly to infections. May very rarely cause hypertension,
hyperglycemia, and may affect behavior/central nervous system (excitation, vertigo, headache, convulsions,
psychosis, hallucinations), and eye problems (glaucoma, mydriasis). Dermatologic effects may include impaired
wound healing, thin fragile skin, facial erythema, petechiae and ecchymoses.

Section 12. Ecological Information
Not available.
Ecotoxicity
BOD5 and CODNot available.
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The products of degradation are more toxic than the product itself.
Toxicity of the Products
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation
Triamcinolone Hexacetonide

Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.

Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada).
DSCL (EEC)This product is not classified according Not applicable.
to the EU regulations.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
Triamcinolone Hexacetonide
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3930000
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-(3,3-dimethylbutyrate)
CAS REGISTRY NUMBER :
5611-51-8
BEILSTEIN REFERENCE NO. :
1413888
LAST UPDATED :
199712
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C30-H41-F-O7
MOLECULAR WEIGHT :
532.71
WISWESSER LINE NOTATION :
T F5 E5 B666 GO IO RV AHTTTT&J A1 BF CQ E1 FV1OV1X1&1&1 H1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
40 mg/kg
SEX/DURATION :
female 10-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,747,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
40 mg/kg
SEX/DURATION :
female 10-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,747,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
2 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
46IEAC "Current Research Trends in Prenatal Craniofacial Development, Proceedings of an International Conference, 1980," Pratt, R.M., and R.L. Christiansen, eds., New York, Elsevier Science Pub. Co., Inc., 1980 Volume(issue)/page/year: -,387,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
2 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919- Volume(issue)/page/year: 58(Spec Iss A),384,197
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
2 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
IMNGBK Immunogenetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1974- Volume(issue)/page/year: 13,443,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5557 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1088 (estimated) No. of Female Employees: 744 (estimated)

 Safety Information

RIDADR NONH for all modes of transport

 Articles28

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 Synonyms

Aristospan (TN)
Tiamcinoloni hexacetonidum [INN]
EINECS 227-031-4
UNII-I7GT1U99Y9
TATBA
Lederspan
Triamcinolone esacetonide [DCIT]
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