oxybutynin

Modify Date: 2024-01-02 13:21:38

oxybutynin Structure
oxybutynin structure
Common Name oxybutynin
CAS Number 5633-20-5 Molecular Weight 357.486
Density 1.1±0.1 g/cm3 Boiling Point 494.4±45.0 °C at 760 mmHg
Molecular Formula C22H31NO3 Melting Point 125 - 130ºC
MSDS N/A Flash Point 252.8±28.7 °C

 Use of oxybutynin


Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.Target: mAChROxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination (urge incontinence), by decreasing muscle spasms of the bladder. Oxybutynin competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic, but at concentrations far above those used clinically. Oxybutynin is available orally in generic formulation or as the brand-names Ditropan, Lyrinel XL, or Ditrospam, as a transdermal patch under the brand name Oxytrol, and as a topical gel under the brand name Gelnique. Oxybutynin is also a possible treatment of hyperhidrosis (hyper-active sweating) [1-3].

 Names

Name oxybutynin
Synonym More Synonyms

 oxybutynin Biological Activity

Description Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.Target: mAChROxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination (urge incontinence), by decreasing muscle spasms of the bladder. Oxybutynin competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic, but at concentrations far above those used clinically. Oxybutynin is available orally in generic formulation or as the brand-names Ditropan, Lyrinel XL, or Ditrospam, as a transdermal patch under the brand name Oxytrol, and as a topical gel under the brand name Gelnique. Oxybutynin is also a possible treatment of hyperhidrosis (hyper-active sweating) [1-3].
Related Catalog
References

[1]. Tupker, R.A., A.M. Harmsze, and V.H. Deneer, Oxybutynin therapy for generalized hyperhidrosis. Archives of dermatology, 2006. 142(8): p. 1065-1086.

[2]. Mijnhout, G., et al., Oxybutynin: dry days for patients with hyperhidrosis. Neth J Med, 2006. 64(9): p. 326-8.

[3]. Schollhammer, M. and L. Misery, Treatment of hyperhidrosis with oxybutynin. Archives of dermatology, 2007. 143(4): p. 543-551.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 494.4±45.0 °C at 760 mmHg
Melting Point 125 - 130ºC
Molecular Formula C22H31NO3
Molecular Weight 357.486
Flash Point 252.8±28.7 °C
Exact Mass 357.230408
PSA 49.77000
LogP 5.19
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.546
Storage condition -20°C

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: Oxybutynin
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Oxybutynin
CAS number:5633-20-5

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C22H31NO3
Molecular weight:357.5

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

HS Code 2922509090

 Synthetic Route

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oxybutynin Structure

oxybutynin

CAS#:5633-20-5

Literature: WO2009/122429 A2, ; Page/Page column 7 ;

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oxybutynin Structure

oxybutynin

CAS#:5633-20-5

Literature: US2009/247628 A1, ; Page/Page column 53-54 ; US 20090247628 A1

~%

oxybutynin Structure

oxybutynin

CAS#:5633-20-5

Literature: WO2009/122429 A2, ; Page/Page column 6-7 ;

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

cyclohexyl(hydroxy)phénylacétate de 4-(diéthylamino)but-2-yn-1-yle
Cystrin
Oxybutyninum
EINECS 202-516-5
4-(Diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate
Oxybutynine
benzeneacetic acid, a-cyclohexyl-a-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester
a-Phenylcyclohexaneglycolic acid 4-(diethylamino)-2-butynyl ester
a-Cyclohexyl-a-hydroxybenzene acetic acid 4-(diethylamino)-2-butynyl ester
Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester
Oxybutynin Base
4-(Diethylamino)but-2-in-1-ylcyclohexyl(hydroxy)phenylacetat
4-Diethylamino-2-butynyl phenyl cyclohexylglycolate
MFCD00865252
Oxybutinin
Lyrinel XL
4-(Diethylamino)-2-butyn-1-yl cyclohexyl(hydroxy)phenylacetate
Pollakisu
4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
Oxytrol
Oxybutynin
Ditropan
Oxibutinina
Oxibutyninum
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