Acetylcarnosine

Modify Date: 2024-01-02 09:32:32

Acetylcarnosine Structure
Acetylcarnosine structure
 Common Name Acetylcarnosine
CAS Number 56353-15-2 Molecular Weight 268.269
Density 1.3±0.1 g/cm3 Boiling Point 775.9±60.0 °C at 760 mmHg
Molecular Formula C11H16N4O4 Melting Point 253 - 260ºC
MSDS N/A Flash Point 423.0±32.9 °C

 Use of Acetylcarnosine


N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic drug in treatment of human cataracts[1].

 Names

Name N-acetylcarnosine
Synonym More Synonyms

 Acetylcarnosine Biological Activity

Description N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic drug in treatment of human cataracts[1].
Related Catalog
In Vivo Right eyes of the rabbits (male grey chinchilla rabbits aged 3-4 months weighing 2-3 k) are instilled with 80 μL of formulation A containing 1 % N-Acetylcarnosine. The N-Acetylcarnosine prodrug eye drops optimize the clinical effects for the treatment of ophthalmic disorders (such as prevention and reversal of cataracts in human and animal eyes)[1].
References

[1]. Babizhayev MA, et al. N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts. Peptides. 2001 Jun;22(6):979-94.

[2]. Dubois VD, et al. N-acetylcarnosine (NAC) drops for age-related cataract. Cochrane Database Syst Rev. 2017 Feb 28;2:CD009493.

[3]. Babizhayev MA, et al. Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases. Drug Metabol Drug Interact. 2009;24(2-4):275-323.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 775.9±60.0 °C at 760 mmHg
Melting Point 253 - 260ºC
Molecular Formula C11H16N4O4
Molecular Weight 268.269
Flash Point 423.0±32.9 °C
Exact Mass 268.117157
PSA 124.18000
LogP -2.56
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.563
Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

 Safety Information

Hazard Codes Xi
HS Code 2942000000

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
N-Acetyl-β-alanyl-L-histidine
L-Histidine, N-acetyl-β-alanyl-
Acetylcarnosine
N-ACETYL-L-CARNOSINE
N-Aceyl-L-Carnosine
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