Sodium oxamate
Modify Date: 2024-01-02 10:31:30
Sodium oxamate structure
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Common Name | Sodium oxamate | ||
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| CAS Number | 565-73-1 | Molecular Weight | 111.032 | |
| Density | N/A | Boiling Point | 306.3ºC at 760 mmHg | |
| Molecular Formula | C2H2NNaO3 | Melting Point | 300 °C | |
| MSDS | Chinese USA | Flash Point | 139ºC | |
Use of Sodium oxamateOxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3]. |
| Name | oxamic acid sodium salt |
|---|---|
| Synonym | More Synonyms |
| Description | Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3]. |
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| Related Catalog | |
| In Vitro | Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1]. Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2]. Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2]. Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2]. Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2]. Cell Proliferation Assay[2] Cell Line: CNE-1 and CNE-2 cells Concentration: 10 μM Incubation Time: 24-72 hours Result: Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively. Apoptosis Analysis[2] Cell Line: 0, 20, 50 and 100 mM Concentration: 10 μM Incubation Time: 48 hours Result: Showed the increasement of early and late apoptotic cells in a dose-dependent manner. Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3. Cell Cycle Analysis[2] Cell Line: 0, 20, 50 and 100 mM Concentration: 10 μM Incubation Time: 24 hours Result: Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase. |
| In Vivo | Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2]. Animal Model: Female Balb/c nude mice injected with CNE-1 cells[2] Dosage: 750 mg/kg Administration: Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks Result: Inhibited the tumor growth when compared to either oxamate alone or irradiation alone. |
| Boiling Point | 306.3ºC at 760 mmHg |
|---|---|
| Melting Point | 300 °C |
| Molecular Formula | C2H2NNaO3 |
| Molecular Weight | 111.032 |
| Flash Point | 139ºC |
| Exact Mass | 110.993240 |
| PSA | 83.22000 |
| Storage condition | Store at RT. |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | F: Flammable; |
| Risk Phrases | R22;R24/25 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2924199090 |
| HS Code | 2924199090 |
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| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... |
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Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells.
Oncotarget 5(23) , 11886-96, (2015) Higher rate of glycolysis has been long observed in cancer cells, as a vital enzyme in glycolysis, lactate dehydrogenase A (LDH-A) has been shown with great potential as an anti-cancer target. Accumul... |
| Sodium oxamate |
| MFCD00044553 |
| sodium,oxamate |
| Acetic acid, 2-amino-2-oxo-, sodium salt (1:1) |
| Sodium amino(oxo)acetate |
| Oxalic acid monoamide sodium salt |
| Acetic acid, aminooxo-, monosodium salt |
| EINECS 209-290-5 |
| OXAMIC ACID SODIUM SALT |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Sodium oxamate
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- Product Name: Sodium oxamate
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Oxamic acid sodium salt
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
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