U 44069

Modify Date: 2024-01-02 13:18:09

U 44069 Structure
U 44069 structure
Common Name U 44069
CAS Number 56985-32-1 Molecular Weight 350.49
Density 1.1±0.1 g/cm3 Boiling Point 519.7±35.0 °C at 760 mmHg
Molecular Formula C21H34O4 Melting Point N/A
MSDS N/A Flash Point 176.1±19.4 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

 Use of U 44069


U-44069 is a stable prostaglandin (PG) H2 analogue and a potent vasoconstrictor. U-44069 induces Ca influx at preglomerular vessels[1].

 Names

Name 9,11-Dideoxy-9α,11α-epoxymethanoprostaglandin F2α
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 519.7±35.0 °C at 760 mmHg
Molecular Formula C21H34O4
Molecular Weight 350.49
Flash Point 176.1±19.4 °C
Exact Mass 350.245697
PSA 66.76000
LogP 3.88
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.548

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H319-H336
Supplemental HS Repeated exposure may cause skin dryness or cracking.
Precautionary Statements P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn
Risk Phrases 20/21/22
Safety Phrases 22-36
RIDADR UN1231 - class 3 - PG 2 - Methyl acetate, solution

 Articles26

More Articles
Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.

Prostaglandins Leukot. Essent. Fatty Acids 76(5) , 299-308, (2007)

The role of endothelin, PAF and thromboxane A2 in airway hyperreactivity (AHR) to carbachol induced by ovalbumin sensitization and challenge in Balb/c mice was investigated. Ovalbumin sensitization an...

Glibenclamide inhibits agonist-induced vasoconstriction of placental chorionic plate arteries.

Placenta 27(6-7) , 660-8, (2006)

Preliminary data suggest that K(ATP) channels may be expressed in placental arteries and veins [Wareing M, Turner C, Greenwood SL, Baker PN, Fyfe GK. Expression of mRNA encoding K+ channels in chorion...

Substrate binding is the rate-limiting step in thromboxane synthase catalysis.

J. Biol. Chem. 276(18) , 14737-43, (2001)

Thromboxane synthase (TXAS) is a "non-classical" cytochrome P450. Without any need for an external electron donor, or for a reductase or molecular oxygen, it uses prostaglandin H2 (PGH2) to catalyze e...

 Synonyms

5-Heptenoic acid, 7-[(1S,4R,5S,6R)-5-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl]-, (5Z)-
(Z)-7-[(1R,2S,3R,4S)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxabicyclo[2.2.1]heptan-3-yl]hept-5-enoic acid
(5Z)-7-{(1S,4R,5S,6R)-5-[(1E,3S)-3-Hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl}-5-heptenoic acid
MFCD00135237
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