DQn-1
Modify Date: 2024-01-02 20:55:11
DQn-1 structure
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Common Name | DQn-1 | ||
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| CAS Number | 57343-54-1 | Molecular Weight | 343.77 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H14ClN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DQn-1DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1]. |
| Name | 4-[(2,4-diamino-5-chloroquinazolin-6-yl)methylamino]benzoic acid |
|---|
| Description | DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1]. |
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| Related Catalog | |
| In Vitro | DQn-1 抑制 Mycobacterium tuberculosis，MIC90 值分别为 0.03 µM 和 1 µM[1]。 |
| In Vivo | DQn-1 (5-10 mg/kg; p.o. for 8 days) 未能检测到小鼠 Mtb 负荷有任何显着降低[1]。 |
| References |
| Molecular Formula | C16H14ClN5O2 |
|---|---|
| Molecular Weight | 343.77 |
| Exact Mass | 343.08400 |
| PSA | 128.61000 |
| LogP | 2.69110 |
|
~90%
DQn-1 CAS#:57343-54-1 |
| Literature: Hynes; Kumar; Tomazic; Washtien Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1515 - 1519 |
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~%
DQn-1 CAS#:57343-54-1 |
| Literature: Hynes; Kumar; Tomazic; Washtien Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1515 - 1519 |
|
~%
DQn-1 CAS#:57343-54-1 |
| Literature: Hynes; Kumar; Tomazic; Washtien Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1515 - 1519 |
| Precursor 3 | |
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| DownStream 0 | |