DQn-1

Modify Date: 2024-01-02 20:55:11

DQn-1 structure	Common Name	DQn-1
	CAS Number	57343-54-1	Molecular Weight	343.77
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₄ClN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DQn-1

DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1].

Name	4-[(2,4-diamino-5-chloroquinazolin-6-yl)methylamino]benzoic acid

Description	DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	DQn-1 抑制 Mycobacterium tuberculosis，MIC90 值分别为 0.03 µM 和 1 µM[1]。
In Vivo	DQn-1 (5-10 mg/kg; p.o. for 8 days) 未能检测到小鼠 Mtb 负荷有任何显着降低[1]。
References	[1]. Kumar A, et, al. A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis. ACS Infect Dis. 2015 Dec 11;1(12):604-14.