Ethacizine hydrochloride

Modify Date: 2024-01-10 13:47:03

Ethacizine hydrochloride Structure
Ethacizine hydrochloride structure
Common Name Ethacizine hydrochloride
CAS Number 57530-40-2 Molecular Weight 449.99400
Density N/A Boiling Point 576.7ºC at 760mmHg
Molecular Formula C22H28ClN3O3S Melting Point N/A
MSDS N/A Flash Point 302.6ºC

 Use of Ethacizine hydrochloride


Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].

 Names

Name ethyl N-[10-[3-(diethylamino)propanoyl]phenothiazin-2-yl]carbamate,hydrochloride
Synonym More Synonyms

 Ethacizine hydrochloride Biological Activity

Description Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].
Related Catalog
In Vivo NIK-244 (1-300 ug) injects directly into the SA node and PM preparations shows negative chronotropic, negative inotropic and coronary vasodilator[1].
References

[1]. Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56(1):1-12.

[2]. Satoh H, et al. An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.Br J Pharmacol. 1989 Nov;98(3):827-32.Med Chem. 2019 Nov 6:115132.

 Chemical & Physical Properties

Boiling Point 576.7ºC at 760mmHg
Molecular Formula C22H28ClN3O3S
Molecular Weight 449.99400
Flash Point 302.6ºC
Exact Mass 449.15400
PSA 90.67000
LogP 5.99680

 Synonyms

Ethacizine hydrochloride