L-γ-Glutamyl-S-nitroso-L-cysteinylglycine

Modify Date: 2024-01-02 23:38:08

L-γ-Glutamyl-S-nitroso-L-cysteinylglycine structure	Common Name	L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
	CAS Number	57564-91-7	Molecular Weight	336.322
	Density	1.7±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₆N₄O₇S	Melting Point	>170ºC (dec.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of L-γ-Glutamyl-S-nitroso-L-cysteinylglycine

Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].

Name	S-nitrosoglutathione
Synonym	More Synonyms

Description	Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vitro	Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity[5].
In Vivo	Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20[3]. Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, butup-regulates endothelial NOS expression in the flap vessels[4]. Animal Model: Male Lewis rats[4]. Dosage: 0.2 and 0.6 mg/kg. Administration: Slow intravenous injection via the opposite femoral vein into each rat. Result: Animals treated with 0.2 mg of GSNO per kilogram before reperfusion had an intermediate survival rate (40.2 ± 4.9%). Although 0.6 mg/kg of GSNO showed a better rescuing effect than 150 mg/kg of NAC, there was no significant difference between the groups.
References	[1]. Marie-Lynda Bouressam, et al. S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT 1 receptor responses: A possible role of S-nitrosation. Br J Pharmacol. 2019 Jun;176(12):2049-2062. [2]. D E Jensen, et al. S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme. Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):659-68. [3]. Caneta Brown, et al. The effects of S-nitrosoglutathione and S-nitroso-N-acetyl-D, L-penicillamine in a rat model of pre-eclampsia. J Nat Sci Biol Med. 2013 Jul;4(2):330-5. [4]. Yur-Ren Kuo, et al. Nitrosoglutathione promotes flap survival via suppression of reperfusion injury-induced superoxide and inducible nitric oxide synthase induction. J Trauma. 2004 Nov;57(5):1025-31. [5]. Eva Nozik-Grayck, et al. Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1057-65.

Density	1.7±0.1 g/cm3
Melting Point	>170ºC (dec.)
Molecular Formula	C₁₀H₁₆N₄O₇S
Molecular Weight	336.322
Exact Mass	336.073975
PSA	213.55000
LogP	-0.26
Index of Refraction	1.656
Storage condition	−20°C

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0558000

CHEMICAL NAME :: Glycine, N-(N-L-gamma-glutamyl-2-nitroso-L-cysteinyl)-

CAS REGISTRY NUMBER :: 57564-91-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H16-N4-O7-S

MOLECULAR WEIGHT :: 336.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 5 umol/plate

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,3847,1986

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MC0558000
HS Code	2930909090

Precursor 9
CAS#:70-18-8 Glutathione CAS#:116303-47-0 4,7-dimethyl-1,... CAS#:540-80-7 t-butyl nitrite CAS#:541-42-4 Isopropyl nitrite
CAS#:109-95-5 Ethanol solution CAS#:10288-17-2 2-chloroethyl n... CAS#:41051-51-8 2-ethoxyethyl n... CAS#:10311-10-1 2-bromoethyl nitrite
CAS#:110-46-3 Isopentyl nitrite
DownStream 8
CAS#:59-89-2 4-Nitrosomorpholine CAS#:27025-41-8 L(-)-Glutathione CAS#:70-18-8 Glutathione CAS#:67776-06-1 N-Acetyl-3-(nit...
CAS#:599-71-3 Benzenesulfohyd... CAS#:97512-84-0 (2S)-2-amino-5-... CAS#:1116-54-7 2,2'-(Nitrosoim... CAS#:13081-14-6 L-CYSTEINE-GLUT...

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Down regulation of NO signaling in Trypanosoma cruzi upon parasite-extracellular matrix interaction: changes in protein modification by nitrosylation and nitration.

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Adhesion of the Trypanosoma cruzi trypomastigotes, the causative agent of Chagas' disease in humans, to components of the extracellular matrix (ECM) is an important step in host cell invasion. The sig...

Lipopolysaccharides Promote S-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophages in Vivo.

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LKB1 (liver kinase B1) plays important roles in tumor suppression, energy metabolism, and, recently, in innate immune responses. However, how LKB1 is regulated under physiological or pathological cond...

S-nitrosylation triggers ABI5 degradation to promote seed germination and seedling growth.

Nat. Commun. 6 , 8669, (2015)

Plant survival depends on seed germination and progression through post-germinative developmental checkpoints. These processes are controlled by the stress phytohormone abscisic acid (ABA). ABA regula...

L-γ-Glutamyl-S-nitroso-L-cysteinylglycine

glycine, N-(N-L-γ-glutamyl-S-nitroso-L-cysteinyl)-

Glycine, L-γ-glutamyl-S-nitroso-L-cysteinyl-

S-Nitroso-L-glutathione

S-NITROSOGLUTATHIONE

MFCD00214341

EINECS 248-170-7

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
Price: ￥708.0/10mg ￥7358.0/250mg ￥1898.0/50mg
Purity: 97.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: GSNO
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: S-nitrosoglutathione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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