carazolol

Modify Date: 2024-01-05 23:30:59

carazolol Structure
carazolol structure
Common Name carazolol
CAS Number 57775-29-8 Molecular Weight 298.38
Density 1.2±0.1 g/cm3 Boiling Point 531.2±40.0 °C at 760 mmHg
Molecular Formula C18H22N2O2 Melting Point 133-137 °C
MSDS Chinese USA Flash Point 275.1±27.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of carazolol


Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist[1].

 Names

Name carazolol hcl
Synonym More Synonyms

 carazolol Biological Activity

Description Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist[1].
Related Catalog
Target

β1 adrenoceptor

β2 adrenoceptor

β3 adrenoceptor

In Vivo Carazolol (0.01 mg/kg; i.m.; once) shows no significant side effects[2]. Animal Model: Kivircik sheeps, 25-45 kg, nonpregnant[2] Dosage: 0.01 mg/kg Administration: Intramuscular injection, once Result: Urea, creatinin, ALT, ALP, GGT, LDH, Ca, P, T.Protein, Mg, Cu levels in blood serum parameters were found to be in normal level however serum Fe, Zn levels were decreased.
References

[1]. A Méjean, et al. Carazolol: a potent, selective beta 3-adrenoceptor agonist. Eur J Pharmacol. 1995 Nov 30;291(3):359-66.

[2]. Remzi Gonul, et al. Effects of carazolol on electrocadiographic and trace element status in sheeps. Insights Vet Sci. 2018; 2: 001- 004.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 531.2±40.0 °C at 760 mmHg
Melting Point 133-137 °C
Molecular Formula C18H22N2O2
Molecular Weight 298.38
Flash Point 275.1±27.3 °C
Exact Mass 298.168121
PSA 57.28000
LogP 3.59
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.652

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UA8685000
CHEMICAL NAME :
2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((1-methylethyl)amino)-
CAS REGISTRY NUMBER :
57775-29-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H22-N2-O2
MOLECULAR WEIGHT :
298.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
10 ug/kg
SEX/DURATION :
female 16 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,191,1983

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S26
RIDADR NONH for all modes of transport
RTECS UA8685000
HS Code 2933990090

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

Conduction
1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
carazolol
CARAZOLOL HYDROCHLORIDE
1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol
EINECS 260-945-1
1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol
suacron
MFCD03428052
2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]-
Carazololum
Conducton
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