Proctolin

Modify Date: 2024-01-10 09:48:02

Proctolin structure	Common Name	Proctolin
	CAS Number	57966-42-4	Molecular Weight	648.75100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₄₈N₈O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Proctolin

Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.

Name	2-[[1-[2-[[2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid
Synonym	More Synonyms

Description	Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Natural Products >> Others Peptides
In Vitro	Proctolin can increase the frequency of action potentials, increase the amplitude of muscle contraction, and initiate activity in quiescent systems[1]. In the arthropods, Proctolin acts as a neuromodulator and possibly as a neurohormone. It does not appear to function as a conventional neurotransmitter[2]. Proctolin is a pentapeptide with the mature peptide of RYLPT, and it is the first insect neuropeptide to be sequenced and chemically characterized. The first identification of a Proctolin precursor gene is CG7105 in D. melanogaster. Although a previous study showed that Proctolin is absent in B. mori, this pentapeptide is recently identified in a proteomic analysis of B. mori wings. However, the Bombyx Proctolin gene does not produce a mature peptide because cleavage sites are not present at the N-terminal and C-terminal of the RYLPT sequence, and a similar gene is observed in C. suppressalis. Therefore, a true Proctolin has been considered to be not observed in B. mori and C. suppressalis[3].
References	[1]. McGrath LL, et al. De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. BMC Genomics. 2016 Jan 16;17:63. [2]. Orchard I, et al. Proctolin: a review with emphasis on insects. J Neurobiol. 1989 Jul;20(5):470-96. [3]. Xu G, et al. Identification and expression profiles of neuropeptides and their G protein-coupled receptors in the rice stem borer Chilo suppressalis. Sci Rep. 2016 Jun 29;6:28976.

Molecular Formula	C₃₀H₄₈N₈O₈
Molecular Weight	648.75100
Exact Mass	648.36000
PSA	283.76000
LogP	2.83220
Storage condition	2-8℃

Arg-tyr-leu-pro-thr

Proctolin

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Proctolin
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Proctolin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
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Taiwan Oyi peptide Co. Ltd
China
Product Name: ARG--TYR--LEU--PRO-THR
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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Price: $108/1mg

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